{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T22:35:22Z","timestamp":1773268522065,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,3,28]],"date-time":"2019-03-28T00:00:00Z","timestamp":1553731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"None."}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Asian J Endoscop Surgery"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>We investigated the indications for laparoscopic liver resection (LLR) of mass\u2010forming intrahepatic cholangiocarcinoma (MF\u2010ICC), including the need for lymph node dissection for improved postoperative prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study involved 36 patients who underwent surgery for solitary peripheral MF\u2010ICC. Fifteen patients underwent LLR, and 21 underwent open liver resection (OLR). Surgical outcomes and prognostic factors were investigated to determine the indications for LLR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant differences were observed in perioperative outcomes between patients who underwent LLR and OLR. A significantly worse disease\u2010free survival (DFS) rate was observed in patients who preoperatively had a tumor diameter \u22653\u2009cm, vascular invasion on diagnostic imaging, and elevated serum carbohydrate antigen (CA) 19\u20109 and carcinoembryonic antigen (CEA) levels. A significantly worse overall survival (OS) rate was observed in patients with a tumor diameter \u22653\u2009cm, vascular invasion on diagnostic imaging, and elevated serum CA19\u20109 levels. Therefore, a tumor diameter \u22653\u2009cm, vascular invasion on diagnostic imaging, and elevated serum CA19\u20109 and CEA levels were determined to be preoperative prognostic factors. DFS and OS rates were significantly better in patients without these factors. Moreover, in six patients without these factors who underwent LLR, neither lymph node metastasis nor postoperative recurrence was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A tumor diameter \u22653\u2009cm, vascular invasion on diagnostic imaging, and elevated serum CA19\u20109 and CEA levels are preoperative prognostic factors for peripheral MF\u2010ICC. LLR is indicated for patients without these factors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ases.12703","type":"journal-article","created":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T06:59:23Z","timestamp":1553842763000},"page":"46-58","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Indications for laparoscopic liver resection of mass\u2010forming intrahepatic cholangiocarcinoma"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6716-6377","authenticated-orcid":false,"given":"Masahiko","family":"Kinoshita","sequence":"first","affiliation":[{"name":"Department of Hepato\u2010Biliary\u2010Pancreatic Surgery Osaka City General Hospital  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akishige","family":"Kanazawa","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Biliary\u2010Pancreatic Surgery Osaka City General Hospital  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