{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T09:52:52Z","timestamp":1783504372538,"version":"3.55.0"},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T00:00:00Z","timestamp":1580256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Asian J Endoscop Surgery"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The application of hyperthermic intraperitoneal chemotherapy (HIPEC) in colorectal and appendix cancer at risk of peritoneal seeding is an appealing strategy to prevent peritoneal metastases. Here, we present the technical details and postoperative outcomes of laparoscopic HIPEC performed with prophylactic intent in three patients with low\u2010grade appendiceal neoplasm (LAMN) considered at risk of peritoneal recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Surgical Technique<\/jats:title><jats:p>Three patients with LAMN previously treated outside our department were selected for second\u2010look laparoscopic exploration and HIPEC. The study received institutional review board approval. A Hasson trocar was inserted around the umbilicus. Four additional 10\u2010mm trocars were inserted\u2014one each in the left and right upper and lower quadrants. After full abdominal exploration, laparoscopic cytoreductive surgery was performed. Perfusion catheters were inserted through the four lateral trocars in the abdominal quadrants. HIPEC was performed with mitomycin 12\u2009mg\/m<jats:sup>2<\/jats:sup> and cisplatin 90\u2009mg\/m<jats:sup>2<\/jats:sup> for 60\u2009minutes at a target temperature of 41.0\u00b0C. The postoperative course was uneventful, except for an episode of fluid leak due to dural tear (treated with supine bed rest for 48\u2009hours and resulting in no adverse sequelae). The median length of hospital stay was 11\u2009days. After a median follow\u2010up of 36\u2009months, all patients were asymptomatic with no evidence of recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Laparoscopic HIPEC for LAMN at risk of peritoneal recurrence appeared to be feasible, safe, and associated with a favorable postoperative outcome. More studies with larger samples of patients and with a standardized design are needed to better analyze the oncological value of this approach.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ases.12784","type":"journal-article","created":{"date-parts":[[2020,1,30]],"date-time":"2020-01-30T03:29:41Z","timestamp":1580354981000},"page":"614-617","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Laparoscopic hyperthermic intraperitoneal chemotherapy for appendiceal tumors"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5764-5606","authenticated-orcid":false,"given":"Antonio","family":"Sommariva","sequence":"first","affiliation":[{"name":"Surgical Oncology of the Esophagus and Digestive Tract Veneto Institute of Oncology (IOV\u2010IRCCS)  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Tonello","sequence":"additional","affiliation":[{"name":"Surgical Oncology of the Esophagus and Digestive Tract Veneto Institute of Oncology (IOV\u2010IRCCS)  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ottavia","family":"De Simoni","sequence":"additional","affiliation":[{"name":"Surgical Oncology of the Esophagus and Digestive Tract Veneto Institute of Oncology (IOV\u2010IRCCS)  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Barina","sequence":"additional","affiliation":[{"name":"Surgical Oncology of the Esophagus and Digestive Tract Veneto Institute of Oncology (IOV\u2010IRCCS)  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Riccardo Rossi","sequence":"additional","affiliation":[{"name":"Surgical Oncology Unit Veneto Institute of Oncology (IOV\u2010IRCCS)  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierluigi","family":"Pilati","sequence":"additional","affiliation":[{"name":"Surgical Oncology of the Esophagus and Digestive Tract Veneto Institute of Oncology (IOV\u2010IRCCS)  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2011.07.001"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000535"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2007.04.002"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-017-6305-5"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.8739"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181af6067"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31817ec31e"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2016-0389"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-013-3189-8"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-016-0996-0"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/02656736.2016.1152514"}],"container-title":["Asian Journal of Endoscopic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fases.12784","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ases.12784","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ases.12784","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ases.12784","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T06:48:55Z","timestamp":1693810135000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ases.12784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,29]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1111\/ases.12784"],"URL":"https:\/\/doi.org\/10.1111\/ases.12784","archive":["Portico"],"relation":{},"ISSN":["1758-5902","1758-5910"],"issn-type":[{"value":"1758-5902","type":"print"},{"value":"1758-5910","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,29]]},"assertion":[{"value":"2019-11-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}