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Many investigations on the biochemical and physiological effects of <jats:styled-content style=\"fixed-case\"><jats:roman>Se<\/jats:roman><\/jats:styled-content> have been previously reported; however, the detailed function of <jats:styled-content style=\"fixed-case\"><jats:roman>Se<\/jats:roman><\/jats:styled-content> in reproduction is not yet clear. We proposed the possibility that <jats:styled-content style=\"fixed-case\"><jats:roman>Se<\/jats:roman><\/jats:styled-content> plays a notable role in progesterone production. The aim of this study was to clarify the effects of <jats:styled-content style=\"fixed-case\"><jats:roman>Se<\/jats:roman><\/jats:styled-content> supplementation on progesterone levels of pregnant Holstein heifers. Eight <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>olstein heifers (\u2212<jats:styled-content style=\"fixed-case\"><jats:roman>Se<\/jats:roman><\/jats:styled-content>) were fed basal diet (containing 0.022\u2009ppm of <jats:styled-content style=\"fixed-case\"><jats:roman>Se<\/jats:roman><\/jats:styled-content>) throughout the experiment. While a 0.3\u2009ppm diet of <jats:styled-content style=\"fixed-case\"><jats:roman>Se<\/jats:roman><\/jats:styled-content> (sodium selenite) was fed to another seven animals (+<jats:styled-content style=\"fixed-case\"><jats:roman>Se<\/jats:roman><\/jats:styled-content>) with basal diet. Blood sampling was carried out every week. Plasma <jats:styled-content style=\"fixed-case\"><jats:roman>Se<\/jats:roman><\/jats:styled-content> concentrations were higher in <jats:styled-content style=\"fixed-case\"><jats:roman>Se<\/jats:roman><\/jats:styled-content>\u2010supplemented cows compared with controls (\u2212<jats:styled-content style=\"fixed-case\"><jats:roman>Se<\/jats:roman><\/jats:styled-content>) (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) throughout the experiment. <jats:styled-content style=\"fixed-case\"><jats:roman>Se<\/jats:roman><\/jats:styled-content> supplementation increased plasma progesterone in the 29\u201339 weeks of pregnancy from 4.98\u2009\u00b1\u20090.64 to 6.86\u2009\u00b1\u20090.49\u2009ng\/mL on average (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The present findings suggest that <jats:styled-content style=\"fixed-case\"><jats:roman>Se<\/jats:roman><\/jats:styled-content> contributes to maintaining the function of the corpus luteum and\/or placenta in the latter period of pregnancy.<\/jats:p>","DOI":"10.1111\/asj.12139","type":"journal-article","created":{"date-parts":[[2013,11,11]],"date-time":"2013-11-11T03:20:48Z","timestamp":1384140048000},"page":"241-246","source":"Crossref","is-referenced-by-count":17,"title":["Effects of selenium supplementation on plasma progesterone concentrations in pregnant heifers"],"prefix":"10.1111","volume":"85","author":[{"given":"Hachiro","family":"Kamada","sequence":"first","affiliation":[{"name":"NARO Institute of Livestock and Grassland Science  Tsukuba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itoko","family":"Nonaka","sequence":"additional","affiliation":[{"name":"NARO Institute of Livestock and Grassland Science  Tsukuba 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