{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:00:25Z","timestamp":1791410425540,"version":"4.3.3"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,12,12]],"date-time":"2013-12-12T00:00:00Z","timestamp":1386806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animal Science Journal"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We recently developed a<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>andrace line that is resistant to mycoplasmal pneumonia of swine (<jats:styled-content style=\"fixed-case\">MPS<\/jats:styled-content>) infection by genetic selection for five generations, and we reported that the immunophenotype of this line is different from that of the non\u2010selected line in terms of changes in peripheral blood leukocyte population after<jats:styled-content style=\"fixed-case\">MPS<\/jats:styled-content>vaccination. This study followed up previous findings demonstrating changes in soluble factors in blood, namely, hormones,<jats:italic><jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ycoplasma hyopneumoniae<\/jats:italic>\u2010specific immunoglobulin G (<jats:styled-content style=\"fixed-case\">IgG<\/jats:styled-content>), and cytokines. These two lines were injected with<jats:styled-content style=\"fixed-case\">MPS<\/jats:styled-content>vaccine on days \u22127 and 0 after blood sampling on those days, and blood samples were collected on days \u221214, \u22127, 0, 2, 7 and 14. We found changes in the levels of many hormones and cytokines in both lines. However, we found that only growth hormone (<jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content>) and interferon (<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>)\u2010\u03b3 levels were statistically different between these two lines.<jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content>concentration was reduced (day 0) and<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3 concentration was increased (day 14) in the<jats:styled-content style=\"fixed-case\">MPS<\/jats:styled-content>\u2010selected line compared with the non\u2010selected line, despite unchanged<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3 messenger<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>expression in blood cells. Although detailed mechanisms underlying these phenotypes remain unsolved, these traits would be useful to improve<jats:styled-content style=\"fixed-case\">MPS<\/jats:styled-content>resistance in pig production and provide an insight into<jats:styled-content style=\"fixed-case\">MPS<\/jats:styled-content>infection.<\/jats:p>","DOI":"10.1111\/asj.12158","type":"journal-article","created":{"date-parts":[[2013,12,13]],"date-time":"2013-12-13T06:31:15Z","timestamp":1386916275000},"page":"365-373","source":"Crossref","is-referenced-by-count":17,"title":["Genetic selection for resistance to mycoplasmal pneumonia of swine (<scp>MPS<\/scp>) in the<scp>L<\/scp>andrace line influences the expression of soluble factors in blood after<scp>MPS<\/scp>vaccine sensitization"],"prefix":"10.1111","volume":"85","author":[{"given":"Tomoyuki","family":"Shimazu","sequence":"first","affiliation":[{"name":"Graduate School of Agricultural Science Tohoku University Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liushiqi","family":"Borjigin","sequence":"additional","affiliation":[{"name":"Graduate School of Agricultural Science Tohoku University Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Katayama","sequence":"additional","affiliation":[{"name":"Graduate School of Agricultural Science Tohoku University Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meihua","family":"Li","sequence":"additional","affiliation":[{"name":"Graduate School of Agricultural Science Tohoku University Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takumi","family":"Satoh","sequence":"additional","affiliation":[{"name":"Graduate School of Agricultural Science Tohoku University Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouichi","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Graduate School of Agricultural Science Tohoku University Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruki","family":"Kitazawa","sequence":"additional","affiliation":[{"name":"Graduate School of Agricultural Science Tohoku University Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang\u2010gun","family":"Roh","sequence":"additional","affiliation":[{"name":"Graduate School of Agricultural Science Tohoku University Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Aso","sequence":"additional","affiliation":[{"name":"Graduate School of Agricultural Science Tohoku University Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katoh","family":"Kazuo","sequence":"additional","affiliation":[{"name":"Graduate School of Agricultural Science Tohoku University Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihito","family":"Suda","sequence":"additional","affiliation":[{"name":"Department of Food, Agriculture and Environment Miyagi University Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Sakuma","sequence":"additional","affiliation":[{"name":"Miyagi Prefecture Animal Industry Experiment Station Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mituru","family":"Nakajo","sequence":"additional","affiliation":[{"name":"Miyagi Prefecture Animal Industry Experiment Station Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichi","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Graduate School of Agricultural Science Tohoku University Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1135(92)90020-T"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cimid.2010.06.004"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsm.35.5.303"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2005.06.009"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-51-4-781"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.62.12.5312-5318.1994"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1261\/rna.79407"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ghir.2008.12.001"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-25-10-1375"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.56.393"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-7207(02)00014-X"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.livsci.2012.03.014"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2007.08.002"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.5713\/ajas.2011.10391"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/141.3.765"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2006.04.009"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2005.07.021"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2007.09.008"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.12.068"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2006.07.004"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2007.11.006"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.70.1065"},{"key":"e_1_2_6_24_1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.2144\/97231bm03","article-title":"Reversal of RT\u2010PCR inhibition observed in heparinized clinical specimens","volume":"23","author":"Neumaier M","year":"1997","journal-title":"BioTechniques"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300-9629(89)90638-5"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2006.11.001"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.22.012703.104702"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2711"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/asj.12058"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1078"},{"key":"e_1_2_6_31_1","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.2460\/ajvr.1984.45.10.1928","article-title":"Mycoplasma hyopneumoniae infection in pigs immunosuppressed by thymectomy and treatment with antithymocyte serum","volume":"45","author":"Tajima M","year":"1984","journal-title":"American Journal of Veterinary Research"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.domaniend.2007.12.003"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.37.3.620-627.1999"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2000.61.1384"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(99)00395-3"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.11.4470-4472.2004"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2007.09.006"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-2427(99)00136-1"}],"container-title":["Animal Science Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fasj.12158","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/asj.12158","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T04:46:09Z","timestamp":1746074769000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/asj.12158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,12]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1111\/asj.12158"],"URL":"https:\/\/doi.org\/10.1111\/asj.12158","archive":["Portico"],"relation":{},"ISSN":["1344-3941","1740-0929"],"issn-type":[{"value":"1344-3941","type":"print"},{"value":"1740-0929","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,12]]}}}