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Previously, we revealed that chronic social defeat induced a mild suppression of feeding in rats with elevated levels of hypothalamic malonyl\u2010<jats:styled-content style=\"fixed-case\">CoA<\/jats:styled-content> which regulates feeding. Therefore, we attempted to elucidate the effects of chronic mild food restriction on behavior and on hypothalamic malonyl\u2010<jats:styled-content style=\"fixed-case\">CoA<\/jats:styled-content>. The chronic mild food restricted rats were fed a restricted diet approximately 80% to 90% amount of diet compared to the control for 5 weeks. Ratios of restriction were adjusted with feed consumption in the chronic social defeat stressed rats. Chronic mild food restricted rats exhibited a suppression of body weight gain similar to that of the chronic social defeat stressed rats. Also these rats showed increased time spent in the center area of an open field (<jats:styled-content style=\"fixed-case\">OF<\/jats:styled-content>), prolonged immobility time in forced swim, increased phosphorylation of hypothalamic adenosine monophosphate\u2010activated protein kinase (<jats:styled-content style=\"fixed-case\">AMPK<\/jats:styled-content>) and acetyl\u2010<jats:styled-content style=\"fixed-case\">CoA<\/jats:styled-content> carboxylase and a decreased concentration of hypothalamic malonyl\u2010<jats:styled-content style=\"fixed-case\">CoA<\/jats:styled-content>. Weight of the adrenal glands, locomotion in an <jats:styled-content style=\"fixed-case\">OF<\/jats:styled-content>, mitogen\u2010activated protein kinase cascade and calcium\/calmodulin\u2010dependent protein kinases <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> in the hippocampus were not affected by chronic mild food restriction. Our findings suggest that chronic mild food restriction activates <jats:styled-content style=\"fixed-case\">AMPK<\/jats:styled-content> following a decreased hypothalamic malonyl\u2010<jats:styled-content style=\"fixed-case\">CoA<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/asj.12255","type":"journal-article","created":{"date-parts":[[2014,7,15]],"date-time":"2014-07-15T15:05:30Z","timestamp":1405436730000},"page":"181-188","source":"Crossref","is-referenced-by-count":11,"title":["Effects of chronic mild food restriction on behavior and the hypothalamic malonyl\u2010<scp>CoA<\/scp> signaling pathway"],"prefix":"10.1111","volume":"86","author":[{"given":"Wataru","family":"Iio","sequence":"first","affiliation":[{"name":"United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology  Fuchu Japan"},{"name":"College of Agriculture Ibaraki University  Ami 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