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Twenty growing barrows (Landrace\u2009\u00d7\u2009Yorkshire) were randomly assigned to four groups according to the<jats:styled-content style=\"fixed-case\">PRRS<\/jats:styled-content>vaccination and<jats:styled-content style=\"fixed-case\">TTS<\/jats:styled-content>. Serum samples were collected from all pigs at days 0, 7, 14, 21, 28, 35, 49 post\u2010vaccination (day 0 defined as the day of vaccination). Pigs were euthanized and samples collected at day 49 post\u2010vaccination. The results showed that<jats:styled-content style=\"fixed-case\">TTS<\/jats:styled-content>tended to increase weight gain and average daily gain (<jats:styled-content style=\"fixed-case\">ADG<\/jats:styled-content>) of pigs (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.1).<jats:styled-content style=\"fixed-case\">PRRS<\/jats:styled-content>vaccine enhanced serum<jats:styled-content style=\"fixed-case\">PRRSV<\/jats:styled-content>\u2010specific antibody, serum virus neutralizing (<jats:styled-content style=\"fixed-case\">SVN<\/jats:styled-content>) antibody and interferon\u2010\u03b3, interleukin (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>)\u201010 and<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b2 concentrations (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The expression of<jats:styled-content style=\"fixed-case\">TLR3<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">TLR7 mRNA<\/jats:styled-content>in lymph nodes were higher in<jats:styled-content style=\"fixed-case\">TTS<\/jats:styled-content>than in the control group after<jats:styled-content style=\"fixed-case\">PRRS<\/jats:styled-content>vaccine inoculation (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<jats:styled-content style=\"fixed-case\">TTS<\/jats:styled-content>diet mitigated lung damage which is induced by<jats:styled-content style=\"fixed-case\">PRRS<\/jats:styled-content>vaccination from microscopic evaluation. These results suggest that dietary<jats:styled-content style=\"fixed-case\">TTS<\/jats:styled-content>could improve growth performance of growing pigs, which may be ascribed to the improved immune response and mitigated lung damage.<\/jats:p>","DOI":"10.1111\/asj.12272","type":"journal-article","created":{"date-parts":[[2014,9,3]],"date-time":"2014-09-03T15:29:48Z","timestamp":1409758188000},"page":"294-304","source":"Crossref","is-referenced-by-count":6,"title":["Threonine and tryptophan supplementation enhance porcine respiratory and reproductive syndrome (<scp>PRRS<\/scp>) vaccine\u2010induced immune responses of growing pigs"],"prefix":"10.1111","volume":"86","author":[{"given":"Shengyu","family":"Xu","sequence":"first","affiliation":[{"name":"Key Laboratory for Animal Disease Resistance Nutrition of Ministry of Education of China Institute of Animal Nutrition Sichuan Agricultural University Ya'an 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