{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:44:53Z","timestamp":1787013893643,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,11,20]],"date-time":"2014-11-20T00:00:00Z","timestamp":1416441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animal Science Journal"],"published-print":{"date-parts":[[2015,3]]},"abstract":"Abstract<\/jats:title>\n \n Glucagon\u2010related peptides, such as glucagon\u2010like peptide (\n GLP<\/jats:styled-content>\n )\u20101,\n GLP<\/jats:styled-content>\n \u20102 and oxyntomodulin (\n OXM<\/jats:styled-content>\n ), are processed from an identical precursor proglucagon. In mammals, all of these peptides are suggested to be involved in the central regulation of food intake. We previously showed that intracerebroventricular administration of chicken\n OXM<\/jats:styled-content>\n and\n GLP<\/jats:styled-content>\n \u20101 significantly suppressed food intake in chicks. Here, we show that central administration of chicken\n GLP<\/jats:styled-content>\n \u20102 potently suppresses food intake in chicks. Male 8\u2010day\u2010old chicks (\n \n G<\/jats:styled-content>\n allus gallus domesticus\n <\/jats:italic>\n ) were used in all experiments. Intracerebroventricular administration of chicken\n GLP<\/jats:styled-content>\n \u20102 significantly suppressed food intake in chicks. Plasma glucose concentration was significantly decreased by chicken\n GLP<\/jats:styled-content>\n \u20102, whereas plasma nonesterified fatty acid concentration was significantly increased. Intracerebroventricular administration of chicken\n GLP<\/jats:styled-content>\n \u20102 did not affect plasma corticosterone concentration. In addition, the anorexigenic effect of\n GLP<\/jats:styled-content>\n \u20102 was not reversed by the corticotropin\u2010releasing factor (\n CRF<\/jats:styled-content>\n ) receptor antagonist \u03b1\u2010helical\n CRF<\/jats:styled-content>\n , suggesting that\n CRF<\/jats:styled-content>\n is not a downstream mediator of the anorexigenic pathway of\n GLP<\/jats:styled-content>\n \u20102 in chicks. Intracerebroventricular administration of an equimolar amount of\n GLP<\/jats:styled-content>\n \u20101 and\n GLP<\/jats:styled-content>\n \u20102, but not\n OXM<\/jats:styled-content>\n , significantly suppressed food intake in both broiler and layer chicks. All our findings suggest that\n GLP<\/jats:styled-content>\n \u20102 functions as a potent anorexigenic peptide in the brain, as well as\n GLP<\/jats:styled-content>\n \u20101, in chicks.\n <\/jats:p>","DOI":"10.1111\/asj.12282","type":"journal-article","created":{"date-parts":[[2014,11,20]],"date-time":"2014-11-20T05:49:44Z","timestamp":1416462584000},"page":"312-318","source":"Crossref","is-referenced-by-count":18,"title":["Intracerebroventricular administration of chicken glucagon\u2010like peptide\u20102 potently suppresses food intake in chicks"],"prefix":"10.1111","volume":"86","author":[{"given":"Kazuhisa","family":"Honda","sequence":"first","affiliation":[{"name":"Department of Bioresource Science Graduate School of Agricultural Science Kobe University Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaoki","family":"Saneyasu","sequence":"additional","affiliation":[{"name":"Department of Bioresource Science Graduate School of Agricultural Science Kobe University Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiko","family":"Shimatani","sequence":"additional","affiliation":[{"name":"Department of Bioresource Science Graduate School of Agricultural Science Kobe University Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Aoki","sequence":"additional","affiliation":[{"name":"Department of Bioresource Science Graduate School of Agricultural Science Kobe University Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Bioresource Science Graduate School of Agricultural Science Kobe University Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiwako","family":"Nakanishi","sequence":"additional","affiliation":[{"name":"Department of Bioresource Science Graduate School of Agricultural Science Kobe University Kobe 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