{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T19:21:31Z","timestamp":1758396091512,"version":"3.40.5"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,12,11]],"date-time":"2014-12-11T00:00:00Z","timestamp":1418256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animal Science Journal"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hepatoprotective effects of<jats:italic><jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>hizopus\u2009oryzae\/<\/jats:italic>\u2005<jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>\u20101 aqueous extract (<jats:styled-content style=\"fixed-case\">RU<\/jats:styled-content>) were demonstrated in carbon tetrachloride (<jats:styled-content style=\"fixed-case\">CCl<jats:sub>4<\/jats:sub><\/jats:styled-content>)\u2010induced liver\u2010injured rats. In order to investigate the<jats:styled-content style=\"fixed-case\">RU<\/jats:styled-content>effects, the rats were administered<jats:styled-content style=\"fixed-case\">RU<\/jats:styled-content>at a dose of 10 or 100\u2009mg\/kg of body weight for 10 days before induction of the liver injury by oral administration of<jats:styled-content style=\"fixed-case\">CCl<jats:sub>4<\/jats:sub><\/jats:styled-content>(125\u2009mg\/kg body weight). (i) Pretreatment with<jats:styled-content style=\"fixed-case\">RU<\/jats:styled-content>caused a significant decrease in serum lactate dehydrogenase (<jats:styled-content style=\"fixed-case\">LDH<\/jats:styled-content>), alanine aminotransferase (<jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content>) and aspartate aminotransferase (<jats:styled-content style=\"fixed-case\">AST<\/jats:styled-content>) activities that were increased by the administration of<jats:styled-content style=\"fixed-case\">CCl<jats:sub>4<\/jats:sub><\/jats:styled-content>. (ii)<jats:styled-content style=\"fixed-case\">RU<\/jats:styled-content>pretreatment (100\u2009mg\/kg) increased 5\u2010bromo\u20102\u2032\u2010deoxyuridine incorporation at 48\u2009h after<jats:styled-content style=\"fixed-case\">CCl<jats:sub>4<\/jats:sub><\/jats:styled-content>treatment in hepatocytes. (iii) Histological hematoxylin and eosin staining of the liver showed that<jats:styled-content style=\"fixed-case\">RU<\/jats:styled-content>pretreatment reduced the damage induced by<jats:styled-content style=\"fixed-case\">CCl<jats:sub>4<\/jats:sub><\/jats:styled-content>administration. (iv) Reverse transcriptase<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>analysis showed<jats:styled-content style=\"fixed-case\">RU<\/jats:styled-content>retreatment caused a transient but significant increase in hepatocyte growth factor (<jats:styled-content style=\"fixed-case\">HGF<\/jats:styled-content>) and a sustained and significant increase in insulin\u2010like growth factor\u2010<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>(<jats:styled-content style=\"fixed-case\">IGF<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>) gene expression in hepatocytes injured by<jats:styled-content style=\"fixed-case\">CCl<jats:sub>4<\/jats:sub><\/jats:styled-content>treatment. From these results, we conclude that oral pre\u2010administration of<jats:styled-content style=\"fixed-case\">RU<\/jats:styled-content>was effective to suppress liver injury induced by the subsequent oral<jats:styled-content style=\"fixed-case\">CCl<jats:sub>4<\/jats:sub><\/jats:styled-content>administration, and<jats:styled-content style=\"fixed-case\">RU<\/jats:styled-content>\u2010induced increase in<jats:styled-content style=\"fixed-case\">IGF<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">HGF<\/jats:styled-content>gene expression may be, even in part, involved in biological actions of<jats:styled-content style=\"fixed-case\">RU<\/jats:styled-content>in rats.<\/jats:p>","DOI":"10.1111\/asj.12328","type":"journal-article","created":{"date-parts":[[2014,12,11]],"date-time":"2014-12-11T12:08:37Z","timestamp":1418299717000},"page":"532-540","source":"Crossref","is-referenced-by-count":3,"title":["Protective effect of aqueous extracts from<i><scp>R<\/scp>hizopus oryzae<\/i>on liver injury induced by carbon tetrachloride in rats"],"prefix":"10.1111","volume":"86","author":[{"given":"Takehito","family":"Suzuki","sequence":"first","affiliation":[{"name":"School of Veterinary Medicine Azabu University Sagamihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideo","family":"Fukuoka","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine Azabu University Sagamihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Setsuo","family":"Ushikoshi","sequence":"additional","affiliation":[{"name":"Ushikoshi Research Institute for Physiology Co., Ltd Sakura 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