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Furthermore, by confocal scanning and quantitative analysis, we find the increased frequency of spindle defects and chromosome misalignment, disturbed redistribution of cortical granules and mitochondria during oocyte <jats:italic>in vitro<\/jats:italic>\u2010aging. Importantly, these aging\u2010associated defective phenotypes can be ameliorated through resveratrol (sirt1 activator) treatment during pig oocyte maturation, providing the evidence for the hypothesis that decreased sirt1 is one of a number of factors contributing to oocyte <jats:italic>in vitro<\/jats:italic>\u2010aging. In summary, our data indicate a role for sirt1 in pig oocytes and uncover a striking beneficial effect of sirt1 expression on aged oocytes.<\/jats:p>","DOI":"10.1111\/asj.12360","type":"journal-article","created":{"date-parts":[[2015,1,20]],"date-time":"2015-01-20T11:06:11Z","timestamp":1421751971000},"page":"826-832","source":"Crossref","is-referenced-by-count":49,"title":["Sirt1 protects pig oocyte against <i>in vitro<\/i> aging"],"prefix":"10.1111","volume":"86","author":[{"given":"Rujun","family":"Ma","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine Nanjing Agricultural University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Nanjing Agricultural University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Animal 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