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The MPS\u2010selected Landrace line showed significantly lower degrees of pulmonary MPS lesions compared with the non\u2010selected Landrace line. When changes in immunity before and after vaccination were compared, the percentage of B cells in the peripheral blood of the MPS\u2010selected Landrace line was significantly lower than that of the non\u2010selected line. Furthermore, the concentration of growth hormone and the mitogen activity of peripheral blood mononuclear cells in the MPS\u2010selected Landrace line showed significantly (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) lower increases after vaccination than the non\u2010selected line. Conversely, the concentration of peripheral blood interferon (IFN)\u2010\u03b3 and salivary immunoglobulin A (IgA) after <jats:italic>Mycoplasma hyopneumoniae<\/jats:italic> vaccination was significantly higher in the MPS\u2010selected Landrace line than in the non\u2010selected line. Gene expression of toll\u2010like receptor (TLR)2 and TLR4 was significantly higher in the MPS\u2010selected Landrace line in immune tissues, with the exception of the hilar lymph nodes. The present results suggest that peripheral blood IFN\u2010\u03b3, salivary IgA TLR2, and TLR4 are important immunological factors influencing the development of MPS lesions.<\/jats:p>","DOI":"10.1111\/asj.12440","type":"journal-article","created":{"date-parts":[[2015,8,11]],"date-time":"2015-08-11T06:24:04Z","timestamp":1439274244000},"page":"321-329","source":"Crossref","is-referenced-by-count":25,"title":["Immunogenic properties of Landrace pigs selected for resistance to mycoplasma pneumonia of swine"],"prefix":"10.1111","volume":"87","author":[{"given":"Liushiqi","family":"Borjigin","sequence":"first","affiliation":[{"name":"Graduate School of Agricultural Science Tohoku University  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Shimazu","sequence":"additional","affiliation":[{"name":"Graduate School of Agricultural Science Tohoku University  Sendai 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