{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:50:47Z","timestamp":1791305447865,"version":"4.3.1"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,9,21]],"date-time":"2015-09-21T00:00:00Z","timestamp":1442793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animal Science Journal"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To determine the effects of puerperal metritis on the immune response, changes in the differential peripheral blood leukocyte counts were analyzed during the peripartum period in cows with or without metritis. Multiparous Holstein cows were examined for uterine health disorders and classified into two groups: healthy (<jats:italic>n<\/jats:italic>\u2009=\u200911) or metritis (<jats:italic>n<\/jats:italic>\u2009=\u20095) cows. The lymphocyte and monocyte counts and the proportion of CD8<jats:sup>+<\/jats:sup>lymphocytes were higher in cows with metritis compared to healthy cows. Moreover, the effects of puerperal metritis on the lymphocyte counts and CD4<jats:sup>+<\/jats:sup>\/CD8<jats:sup>+<\/jats:sup>ratio persisted weeks after the uterine inflammation had self\u2010resolved. Taken together, the findings of the present study indicate the possible long\u2010term alterations of systemic immune responses in cows with puerperal uterine inflammation. \u00a9 2015 Japanese Society of Animal Science<\/jats:p>","DOI":"10.1111\/asj.12516","type":"journal-article","created":{"date-parts":[[2015,9,21]],"date-time":"2015-09-21T12:20:13Z","timestamp":1442838013000},"page":"151-155","source":"Crossref","is-referenced-by-count":13,"title":["Long\u2010term impact of puerperal metritis on the profiles of peripheral blood leukocytes in peripartum dairy cows"],"prefix":"10.1111","volume":"87","author":[{"given":"Fumie","family":"Magata","sequence":"first","affiliation":[{"name":"Graduate School of Animal and Food Hygiene Obihiro University of Agriculture and Veterinary Medicine Obihiro Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuji","family":"Kitaoka","sequence":"additional","affiliation":[{"name":"Graduate School of Animal and Food Hygiene Obihiro University of Agriculture and Veterinary Medicine Obihiro Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikumi","family":"Morino","sequence":"additional","affiliation":[{"name":"Graduate School of Animal and Food Hygiene Obihiro University of Agriculture and Veterinary Medicine Obihiro Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Teramura","sequence":"additional","affiliation":[{"name":"Nippon Beet Sugar Manufacturing Co., Ltd. Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiho","family":"Kawashima","sequence":"additional","affiliation":[{"name":"Graduate School of Animal and Food Hygiene Obihiro University of Agriculture and Veterinary Medicine Obihiro Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingo","family":"Haneda","sequence":"additional","affiliation":[{"name":"Department of Clinical Veterinary Science Obihiro University of Agriculture and Veterinary Medicine Obihiro Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Graduate School of Animal and Food Hygiene Obihiro University of Agriculture and Veterinary Medicine Obihiro Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0065766"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.124.9.217"},{"key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"934","DOI":"10.2460\/ajvr.1994.55.07.934","article-title":"Association between Neutrophil Functions and Periparturient Disorders in Cows","volume":"55","author":"Cai TQ","year":"1994","journal-title":"American Journal of Veterinary Research"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2010-4075"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-07-0065"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-82-5-1181"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2011-3958"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.2460\/ajvr.1976.37.10.1195","article-title":"Effects of parturition and lactation on blood and milk cell concentrations, corticosteroids, and neutrophil phagocytosis in the cow","volume":"37","author":"Guidry AJ","year":"1976","journal-title":"American Journal of Veterinary Research"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2006.03.022"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0450.1989.tb00657.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1262\/jrd.17036"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(99)75238-0"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0531.2002.00351.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anireprosci.2006.03.017"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2007-0096"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0531.2002.00332.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-08-0218"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0093-691X(00)00234-X"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(98)75883-7"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(06)72078-1"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.109.077370"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2011-4695"}],"container-title":["Animal Science Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fasj.12516","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/asj.12516","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T18:47:28Z","timestamp":1748630848000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/asj.12516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,21]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1111\/asj.12516"],"URL":"https:\/\/doi.org\/10.1111\/asj.12516","archive":["Portico"],"relation":{},"ISSN":["1344-3941","1740-0929"],"issn-type":[{"value":"1344-3941","type":"print"},{"value":"1740-0929","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,21]]}}}