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Mice were orally administered either a CLA mixture containing equal amounts of 9c, 11\u2009t\u2010CLA and 10\u2009t, 12c\u2010CLA, or high linoleic acid safflower oil, and allergic dermatitis was induced on the ear by repeated topical applications of oxazolone. Oral administration of the CLA mixture but not the high linoleic safflower oil attenuated the symptoms of allergic dermatitis in both ear weights and clinical scores. This effect was associated with decreased levels of ear interleukin\u20104 (IL\u20104) and plasma immunoglobulin E. The immunomodulatory effects of the CLA isomers were compared by an <jats:italic>in vitro<\/jats:italic> cytokine production assay. The results showed that 9c, 11\u2009t\u2010CLA, the most predominant isomer in animal products, significantly inhibited IL\u20104 and interferon\u2010\u03b3 production from mouse splenocytes with similar potency to 10\u2009t, 12c\u2010CLA. These findings suggest that CLA, a constituent of animal products, has a potentially beneficial effect for amelioration of allergic dermatitis.<\/jats:p>","DOI":"10.1111\/asj.12603","type":"journal-article","created":{"date-parts":[[2016,3,19]],"date-time":"2016-03-19T01:02:55Z","timestamp":1458349375000},"page":"1554-1561","source":"Crossref","is-referenced-by-count":4,"title":["Orally administered conjugated linoleic acid ameliorates allergic dermatitis induced by repeated applications of oxazolone in mice"],"prefix":"10.1111","volume":"87","author":[{"given":"Tomonori","family":"Nakanishi","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Applied Biosciences, Faculty of Agriculture University of Miyazaki  Miyazaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzo","family":"Tokunaga","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Applied Biosciences, Faculty of Agriculture University of Miyazaki  Miyazaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Yamasaki","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Applied Biosciences, Faculty of Agriculture University of Miyazaki  Miyazaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie","family":"Erickson","sequence":"additional","affiliation":[{"name":"Department of Biology Harold Washington City College of Chicago  Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Kawahara","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Applied Biosciences, Faculty of Agriculture University of Miyazaki  Miyazaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,15]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2005.12.008"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.06.049"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M600187-JLR200"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12616"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00005.2007"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01880.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.76.175"},{"key":"e_1_2_5_9_1","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1093\/jn\/138.7.1336","article-title":"Cis\u20109,trans\u201011\u2010conjugated linoleic acid inhibits allergic sensitization and airway inflammation via a PPARgamma\u2010related mechanism in mice","volume":"138","author":"Jaudszus A","year":"2008","journal-title":"Journal of Nutrition"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.106"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2015.03.007"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12069"},{"key":"e_1_2_5_13_1","first-page":"144","article-title":"Contact dermatitis II. 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