{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T14:31:03Z","timestamp":1789655463853,"version":"4.0.1"},"reference-count":11,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,5,27]],"date-time":"2016-05-27T00:00:00Z","timestamp":1464307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animal Science Journal"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Isoleucyl\u2010tRNA synthetase<\/jats:italic> (<jats:italic>IARS<\/jats:italic>) c.235G\u2009&gt;\u2009C (p.V79L) is a causative mutation for a recessive disease called IARS disorder in Japanese black cattle. The disease is involved in weak calf syndrome and is characterized by low birth weight, weakness and poor suckling. The gestation period is often slightly extended, implying that intrauterine growth is retarded. In a previous analysis of 2597 artificial insemination (AI) procedures, we suggested that the <jats:italic>IARS<\/jats:italic> mutation might contribute toward an increase in the incidence of prenatal death. In this study, we extended this analysis to better clarify the association between the <jats:italic>IARS<\/jats:italic> mutation and prenatal death. The <jats:italic>IARS<\/jats:italic> genotypes of 92 animals resulting from crosses between carrier (G\/C) \u00d7 G\/C were 27 normal (G\/G), 55\u2009G\/C and 10 affected animals (C\/C) (expected numbers: 23, 46 and 23, respectively). Compared to the expected numbers, there were significantly fewer affected animals in this population (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), suggesting that more than half of the affected embryos died prenatally. When the number of AI procedures examined was increased to 11\u2009580, the frequency of re\u2010insemination after G\/C \u00d7 G\/C insemination was significantly higher at 61\u2010140 days (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). The findings suggested that the homozygous <jats:italic>IARS<\/jats:italic> mutation not only causes calf death, but also embryonic or fetal death.<\/jats:p>","DOI":"10.1111\/asj.12639","type":"journal-article","created":{"date-parts":[[2016,5,27]],"date-time":"2016-05-27T08:34:07Z","timestamp":1464338047000},"page":"1178-1181","source":"Crossref","is-referenced-by-count":13,"title":["<i>IARS<\/i> mutation causes prenatal death in Japanese Black cattle"],"prefix":"10.1111","volume":"87","author":[{"given":"Takashi","family":"Hirano","sequence":"first","affiliation":[{"name":"Faculty of Agriculture Tokyo University of Agriculture  Atsugi Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamako","family":"Matsuhashi","sequence":"additional","affiliation":[{"name":"Gifu Prefectural Livestock Research Institute  Takayama Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Takeda","sequence":"additional","affiliation":[{"name":"Gifu Prefectural Livestock Research Institute  Takayama Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Hara","sequence":"additional","affiliation":[{"name":"Faculty of Agriculture Tokyo University of Agriculture  Atsugi Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohiko","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Hida Region Livestock Hygiene Service Center  Takayama Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Kita","sequence":"additional","affiliation":[{"name":"Gifu Prefectural Livestock Research Institute  Takayama Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshikazu","family":"Sugimoto","sequence":"additional","affiliation":[{"name":"Shirakawa Institute of Animal Genetics  Nishigo Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Hanzawa","sequence":"additional","affiliation":[{"name":"Faculty of Agriculture Tokyo University of Agriculture  Atsugi Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,27]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/375039"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064036"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1727"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2009.12.005"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2010.09.008"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0442.1999.00221.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1262\/jrd.40.6_j117"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2005.08.004"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0802862105"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.70.1173"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.201100626"}],"container-title":["Animal Science Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fasj.12639","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fasj.12639","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/asj.12639","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T15:07:40Z","timestamp":1694272060000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/asj.12639"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,27]]},"references-count":11,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1111\/asj.12639"],"URL":"https:\/\/doi.org\/10.1111\/asj.12639","archive":["Portico"],"relation":{},"ISSN":["1344-3941","1740-0929"],"issn-type":[{"value":"1344-3941","type":"print"},{"value":"1740-0929","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,27]]}}}