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Whole blood chemiluminescence (WBCL) was measured using the luminol\u2010enhanced zymosan\u2010stimulated chemiluminescence assay. Cows were examined for uterine health disorders and classified into two groups, healthy (<jats:italic>n<\/jats:italic>\u2009=\u200911) and metritis (<jats:italic>n<\/jats:italic>\u2009=\u20095). Metritis had a significant effect on WBCL, with cows with metritis having a higher WBCL. Plasma LPS concentrations in cows with metritis were significantly higher than in healthy cows. To examine the effect of LPS on WBCL, blood was sampled in healthy peripartum cows (1 to 2\u2009weeks prepartum,<jats:italic>n<\/jats:italic>\u2009=\u20098; 0 to 3\u2009weeks postpartum,<jats:italic>n<\/jats:italic>\u2009=\u200911; and 4 to 8\u2009weeks postpartum,<jats:italic>n<\/jats:italic>\u2009=\u20098) and incubated with LPS. At 1 endotoxin units\/mL of LPS, similar to the plasma LPS concentration in cows with metritis, the WBCL increased in cows at 0 to 3\u2009weeks postpartum. Results indicate that the increase in ROS generation and plasma LPS concentration are associated with metritis, and LPS may be responsible for enhanced ROS generation in early postpartum dairy cows.<\/jats:p>","DOI":"10.1111\/asj.12642","type":"journal-article","created":{"date-parts":[[2016,6,17]],"date-time":"2016-06-17T02:46:51Z","timestamp":1466131611000},"page":"248-253","source":"Crossref","is-referenced-by-count":14,"title":["Impact of metritis on the generation of reactive oxygen species by circulating phagocytes and plasma lipopolysaccharide concentration in peripartum dairy cows"],"prefix":"10.1111","volume":"88","author":[{"given":"Fumie","family":"Magata","sequence":"first","affiliation":[{"name":"Graduate School of Animal and Food Hygiene Obihiro University of Agriculture and Veterinary Medicine Obihiro Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikumi","family":"Morino","sequence":"additional","affiliation":[{"name":"Graduate School of Animal and Food Hygiene Obihiro University of Agriculture and Veterinary Medicine Obihiro Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Teramura","sequence":"additional","affiliation":[{"name":"Nippon Beet Sugar Manufacturing Co., Ltd. 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