{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T07:26:29Z","timestamp":1768289189111,"version":"3.49.0"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,9,4]],"date-time":"2016-09-04T00:00:00Z","timestamp":1472947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animal Science Journal"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Satellite cells attached to skeletal muscle fibers play a crucial role in skeletal muscle regeneration. During regeneration, the satellite cells proliferate, migrate to the damaged region, and fuse to each other. Although it is important to determine the cellular mechanisms controlling myoblast behavior, their regulators are not well understood. In this study, we evaluated the roles of<jats:italic>Fbxw7<\/jats:italic>in primary myoblasts and determined its potential as a therapeutic target for muscle disease. We originally found that<jats:italic>Fbxw7\u03b2<\/jats:italic>, one of the E3 ubiquitin ligase<jats:italic>Fbxw7<\/jats:italic>subtypes, negatively regulates differentiation, proliferation and migration of myoblasts and satellite cells on muscle fiber. However, these phenomena were not observed in myoblasts expressing a dominant\u2010negative, F\u2010box deleted<jats:italic>Fbxw7\u03b2,<\/jats:italic>mutant. Our results suggest that myoblast differentiation potential and muscle regeneration can be regulated by<jats:italic>Fbxw7\u03b2.<\/jats:italic><\/jats:p>","DOI":"10.1111\/asj.12687","type":"journal-article","created":{"date-parts":[[2016,9,5]],"date-time":"2016-09-05T03:50:55Z","timestamp":1473047455000},"page":"712-719","source":"Crossref","is-referenced-by-count":7,"title":["<i>Fbxw7\u03b2,<\/i>E3 ubiquitin ligase, negative regulation of primary myoblast differentiation, proliferation and migration"],"prefix":"10.1111","volume":"88","author":[{"given":"Kyungshin","family":"Shin","sequence":"first","affiliation":[{"name":"Division of Radiation Cancer Research Korea Institute of Radiological and Medical Science Seoul South Korea"},{"name":"Department of Biotechnology Korea University Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang\u2010Gu","family":"Hwang","sequence":"additional","affiliation":[{"name":"Division of Radiation Cancer Research Korea Institute of Radiological and Medical Science Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ik Joon","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Korea Cancer Center Hospital Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young\u2010Gyu","family":"Ko","sequence":"additional","affiliation":[{"name":"College of Life Sciences and Biotechnology Korea University Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaemin","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Surgery Hanyang University College of Medicine Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heechung","family":"Kwon","sequence":"additional","affiliation":[{"name":"Division of Radiation Cancer Research Korea Institute of Radiological and Medical Science Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,9,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/bcr2788"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-1320"},{"key":"e_1_2_6_4_1","first-page":"109","article-title":"Circulating tumor cells and epithelial, mesenchymal and stemness markers: characterization of cell subpopulations","volume":"2","author":"Barriere G","year":"2014","journal-title":"Annals of Translational Medicine"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1387\/ijdb.8735956","article-title":"The formation of somite compartments in the avian embryo","volume":"40","author":"Brand\u2010Saberi B","year":"1996","journal-title":"International Journal of Developmental Biology"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2009.00517.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0960-8966(93)90078-X"},{"key":"e_1_2_6_8_1","first-page":"505","article-title":"Cell adhesion and development of skeletal muscle","volume":"188","author":"Cifuentes\u2010Diaz C","year":"1994","journal-title":"Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2009.09.014"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.01.080"},{"key":"e_1_2_6_11_1","first-page":"131","article-title":"The role of TGF\u2010\u03b2 and epithelial\u2010to mesenchymal transition in diabetic nephropathy","volume":"22","author":"Hills CE","year":"2011","journal-title":"Cytokine & Growth Factor Reviews"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diff.2014.01.001"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2013.67"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201303698"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI39104"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65166-8"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1065203"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2010.05.008"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2014.00021"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03155"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000320180"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.09.003"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/35095068"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003707"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1881"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2010.115"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1995.1198"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1996.0135"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20062299"},{"key":"e_1_2_6_30_1","first-page":"1217","article-title":"Regulation of cell\u2010cycle exit and G0\u2010phase maintenance during differentiation by FBXW7","volume":"53","author":"Onoyama I","year":"2008","journal-title":"Tanpakushitsu Kakusan Koso"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2012.11.002"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3035"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.069088"},{"key":"e_1_2_6_34_1","first-page":"4535","article-title":"hCDC4 gene mutations in endometrial cancer","volume":"62","author":"Spruck CH","year":"2002","journal-title":"Cancer Research"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/35095076"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.259"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2009.12.018"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3656"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M312337200"},{"key":"e_1_2_6_40_1","first-page":"87","article-title":"Cell cycle regulation by F\u2010box protein Fbxw7","volume":"100","author":"Tsunematsu R","year":"2009","journal-title":"Fukuoka Igaku Zasshi"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2011.231"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2004.09.083"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2290"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M409226200"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M202668200"}],"container-title":["Animal Science Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fasj.12687","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fasj.12687","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/asj.12687","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T16:44:58Z","timestamp":1749573898000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/asj.12687"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,4]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1111\/asj.12687"],"URL":"https:\/\/doi.org\/10.1111\/asj.12687","archive":["Portico"],"relation":{},"ISSN":["1344-3941","1740-0929"],"issn-type":[{"value":"1344-3941","type":"print"},{"value":"1740-0929","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,4]]}}}