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The MPS lesion score in the three lines was as follows: La line &lt; LaWaDa line &lt; LbWbDb line, with significant differences among the lines. The proportions of myeloid cells and T cells were lower and higher, respectively, in the LaWaDa pigs compared with those in the other two lines. Messenger RNA (mRNA) expression of interleukin (IL)\u20106, IL\u201010, transforming growth factor\u2010\u03b2, and interferon\u2010\u03b3 in peripheral blood was significantly increased after vaccination in the La and LaWaDa lines. IL\u20104 mRNA expression in the LaWaDa line was intermediate to the La and LbWbDb lines. Furthermore, principal component analysis for immune traits and MPS lesions was executed to clarify the characteristics of each pig line. 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