{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T10:34:54Z","timestamp":1762252494789},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,1,12]],"date-time":"2017-01-12T00:00:00Z","timestamp":1484179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007777","name":"Tokyo University of Agriculture","doi-asserted-by":"publisher","award":["No.02, 2006\u20102008"],"award-info":[{"award-number":["No.02, 2006\u20102008"]}],"id":[{"id":"10.13039\/501100007777","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animal Science Journal"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The Japanese quail has several advantages as a low\u2010fat meat bird with high immunity against diseases. Cathelicidins (CATHs) are antimicrobial peptides that play an important role in innate immunity. The aim of this study was to characterize the <jats:italic>CATH<\/jats:italic> cluster in the Japanese quail (<jats:styled-content style=\"fixed-case\"><jats:italic>Coturnix japonica<\/jats:italic><\/jats:styled-content>). The Japanese quail <jats:italic>CATH (CjCATH)<\/jats:italic> cluster, contains four <jats:italic>CATH<\/jats:italic> genes, as in the chicken. The coding sequences of <jats:italic>CjCATHs<\/jats:italic> exhibited &gt;85.3% identity to chicken CATHs. The predicted amino acid sequences of the four <jats:italic>CjCATH<\/jats:italic> genes contained the cathelin\u2010like domain characteristic of CATH proteins. Polymorphisms were detected in the open reading frames (ORFs) of all CjCATH sequences. Two amino acid substitutions were observed in the antimicrobial region of the mature peptide of CjCATH2, and predicted to influence peptide function. <jats:italic>CjCATH1<\/jats:italic> is expressed in lung, heart, bone marrow and bursa of Fabricius (BF). <jats:italic>CjCATH2<\/jats:italic> is expressed in bone marrow. <jats:italic>CjCATH3<\/jats:italic> is expressed in lung, heart, bone marrow, BF, tongue and duodenum. <jats:italic>CjCATHB1<\/jats:italic> is expressed in bone marrow and BF. This study is the first to characterize CATH genes in the Japanese quail, and identifies novel antimicrobial peptide sequences belonging to the cathelicidin family, which may play a role in immunity in this species.<\/jats:p>","DOI":"10.1111\/asj.12752","type":"journal-article","created":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T13:24:30Z","timestamp":1484313870000},"page":"1249-1257","source":"Crossref","is-referenced-by-count":11,"title":["Characterization of the cathelicidin cluster in the Japanese quail (<scp><i>Coturnix japonica<\/i><\/scp>)"],"prefix":"10.1111","volume":"88","author":[{"given":"Taichiro","family":"Ishige","sequence":"first","affiliation":[{"name":"NODAI Genome Research Center Tokyo University of Agriculture  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromi","family":"Hara","sequence":"additional","affiliation":[{"name":"Department of Animal Science Tokyo University of Agriculture  Atsugi 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