{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T02:04:10Z","timestamp":1772503450102,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,4,12]],"date-time":"2017-04-12T00:00:00Z","timestamp":1491955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animal Science Journal"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hydrallantois is the excessive accumulation of fluid in the allantoic cavity in a pregnant animal and is associated with fetal death. We recently identified a recessive missense mutation in the solute carrier family 12, member 1 (<jats:italic><jats:styled-content style=\"fixed-case\">SLC<\/jats:styled-content>12A1<\/jats:italic>) gene (g.62382825G&gt;A, p.Pro372Leu) that is associated with hydrallantois in Japanese Black cattle. Unexpectedly, we found a case of the homozygous risk\u2010allele for <jats:italic><jats:styled-content style=\"fixed-case\">SLC<\/jats:styled-content>12A1<\/jats:italic> in a calf, using a <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>\u2010based direct <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> sequencing test. The homozygote was outwardly healthy up to 3\u00a0months of age and the mother did not exhibit any clinical symptoms of hydrallantois. In order to validate these observations, we performed confirmation tests for the genotype and a diuretic loading test using furosemide, which inhibits the transporter activity of the <jats:styled-content style=\"fixed-case\">SLC<\/jats:styled-content>12A1 protein. The results showed that the calf was really homozygous for the risk\u2010allele. In the homozygous calf, administration of furosemide did not alter urinary Na<jats:sup>+<\/jats:sup> or Cl<jats:sup>\u2212<\/jats:sup> levels, in contrast to the heterozygote and wild\u2010type calves in which these were significantly increased. These results demonstrate that the <jats:italic><jats:styled-content style=\"fixed-case\">SLC<\/jats:styled-content>12A1<\/jats:italic> (g.62382825G&gt;A, p.Pro372Leu) is a hypomorphic or loss\u2010of\u2010function mutation and the hydrallantois with this mutation shows incomplete penetrance in Japanese Black cattle.<\/jats:p>","DOI":"10.1111\/asj.12789","type":"journal-article","created":{"date-parts":[[2017,4,12]],"date-time":"2017-04-12T10:23:25Z","timestamp":1491992605000},"page":"1459-1464","source":"Crossref","is-referenced-by-count":2,"title":["Furosemide loading test in a case of homozygous solute carrier family 12, member 1 (<i><scp>SLC<\/scp>12A1<\/i>) mutation (g.62382825G&gt;A, p.Pro372Leu) in Japanese Black cattle"],"prefix":"10.1111","volume":"88","author":[{"given":"Kiyotoshi","family":"Hasegawa","sequence":"first","affiliation":[{"name":"Shimane Prefecture Livestock Technology Center Koshi, Izumo, Shimane Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Shirakawa Institute of Animal Genetics Japan Livestock Technology Association Odakura, Nishigo, Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichi","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Shimane Prefecture Livestock Technology Center Koshi, Izumo, Shimane Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akifumi","family":"Takano","sequence":"additional","affiliation":[{"name":"Shimane Prefecture Livestock Technology Center Koshi, Izumo, Shimane Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megumi","family":"Takayama","sequence":"additional","affiliation":[{"name":"Shimane Prefecture Livestock Technology Center Koshi, Izumo, Shimane Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Higashi","sequence":"additional","affiliation":[{"name":"Shimane Prefecture Livestock Division Livestock Hygiene Research Office Jinzaioki, Izumo, Shimane Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshikazu","family":"Sugimoto","sequence":"additional","affiliation":[{"name":"Shirakawa Institute of Animal Genetics Japan Livestock Technology Association Odakura, Nishigo, Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuaki","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Shimane Prefecture Livestock Technology Center Koshi, Izumo, Shimane Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,12]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00396.2011"},{"key":"e_1_2_5_3_1","first-page":"45","article-title":"The fetal fluids of domestic animals","volume":"9","author":"Arthur GH","year":"1969","journal-title":"Journal of Reproduction and Fertility"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-013-1331-2"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00350.2012"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00011.2004"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1985.65.3.760"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-001-0521-y"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-013-1370-5"},{"key":"e_1_2_5_10_1","unstructured":"Ministry of Agriculture Forestry and Fisheries.2015a.Statistical Tables of Livestock Mutual Relief (in Japanese).Ministry of Agriculture Forestry and Fisheries Kasumigaseki Tokyo; [cited 8 June 2016]. 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