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In period 1, 12 Holstein steers were kept under a constant room temperature (22\u00b0C) and were administered the intravenous (i.v.) infusion of saline or <jats:styled-content style=\"fixed-case\">TRP<\/jats:styled-content> (38.5\u00a0mg\/kg\/2\u00a0h). Changes in rectal temperature (<jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>), 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> concentration in the cerebrospinal fluid (<jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content>), and other factors involved in thermoregulation were measured. In period 2, the steers received the same treatments as in period 1; however, the room temperature was elevated from 22\u00b0C to 33\u00b0C during i.v. infusion and maintained at 33\u00b0C for 3\u00a0h. 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> concentration in <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> increased following <jats:styled-content style=\"fixed-case\">TRP<\/jats:styled-content> infusion in both periods, and <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content> significantly decreased following <jats:styled-content style=\"fixed-case\">TRP<\/jats:styled-content> infusion only in period 2. The effect of <jats:styled-content style=\"fixed-case\">TRP<\/jats:styled-content> on respiration rate and plasma prolactin and total triiodothyronine concentrations was not significant. These results suggest that increase in <jats:styled-content style=\"fixed-case\">TRP<\/jats:styled-content> supply can attenuate increase in <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content> in response to acute heat stress through the increase in brain 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>, followed by presumable increase in evaporative heat loss from the skin surface in cattle. It is possible that the increase in peripheral blood <jats:styled-content style=\"fixed-case\">TRP<\/jats:styled-content> metabolites could also participate in the hypothermic effect of <jats:styled-content style=\"fixed-case\">TRP<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/asj.12988","type":"journal-article","created":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T06:12:40Z","timestamp":1516342360000},"page":"777-783","source":"Crossref","is-referenced-by-count":11,"title":["Effects of intravenous tryptophan infusion on thermoregulation in steers exposed to acute heat stress"],"prefix":"10.1111","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2019-0644","authenticated-orcid":false,"given":"Madoka","family":"Sutoh","sequence":"first","affiliation":[{"name":"Animal Environment and Health Unit Division of Animal Environment and Waste Management Research Institute of Livestock and Grassland Science National Agriculture and Food Research Organization Tsukuba 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