{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T14:00:30Z","timestamp":1760709630643,"version":"3.37.3"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,5,28]],"date-time":"2018-05-28T00:00:00Z","timestamp":1527465600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The National Key Research and Development Program of China","award":["2016YFD0500505"],"award-info":[{"award-number":["2016YFD0500505"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Science Journal"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The mycotoxin deoxynivalenol (<jats:styled-content style=\"fixed-case\">DON<\/jats:styled-content>) generally exists in cereals and affects human and animal health. The aim of this study is to analyze the impacts of <jats:styled-content style=\"fixed-case\">DON<\/jats:styled-content> in naturally contaminated feed on piglet growth performance and intestinal hormone secretion in the short term. We randomly divided 5\u2010week\u2010old piglets into four groups: Control, <jats:styled-content style=\"fixed-case\">DON<\/jats:styled-content> 1,000, <jats:styled-content style=\"fixed-case\">DON<\/jats:styled-content> 2,000 and <jats:styled-content style=\"fixed-case\">DON<\/jats:styled-content> 3,000 groups. Piglets received a feed naturally contaminated with <jats:styled-content style=\"fixed-case\">DON<\/jats:styled-content> (approximately 400, 1,000, 2,000 or 3,000\u00a0\u03bcg\/kg) for 21\u00a0days. Body weight showed no significant difference following exposure to <jats:styled-content style=\"fixed-case\">DON<\/jats:styled-content>. The balance of anti\u2010oxidation and oxidation was disrupted by <jats:styled-content style=\"fixed-case\">DON<\/jats:styled-content> after 21\u00a0days. The concentration of tumor necrosis factor\u2010alpha (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1) and cyclooxgenase\u20102 (<jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20102) significantly increased (<jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>.001) in all <jats:styled-content style=\"fixed-case\">DON<\/jats:styled-content>\u2010treated groups. Gut anorexigenic hormone secretion of peptide <jats:styled-content style=\"fixed-case\">YY<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">PYY<\/jats:styled-content>) and cholecystokinin (<jats:styled-content style=\"fixed-case\">CCK<\/jats:styled-content>) had a time\u2010 and dose\u2010dependent relationship with <jats:styled-content style=\"fixed-case\">DON<\/jats:styled-content> exposure; however, there was no effect on orexigenic hormone ghrelin secretion. Changes of histomorphology in the jejunum were observed in <jats:styled-content style=\"fixed-case\">DON<\/jats:styled-content>\u2010treated groups, including villi flattening and fusion, and apical necrosis of villi. These results indicated that <jats:styled-content style=\"fixed-case\">DON<\/jats:styled-content> could suppress piglet growth performance and alter gut hormone secretion in the short term.<\/jats:p>","DOI":"10.1111\/asj.13034","type":"journal-article","created":{"date-parts":[[2018,5,29]],"date-time":"2018-05-29T05:54:35Z","timestamp":1527573275000},"page":"1134-1143","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Short\u2010term ingestion of deoxynivalenol in naturally contaminated feed alters piglet performance and gut hormone secretion"],"prefix":"10.1111","volume":"89","author":[{"given":"Ruonan","family":"Li","sequence":"first","affiliation":[{"name":"Jiangsu Provincial Key Laboratory of Gastrointestinal Nutrition and Animal Health College of Animal Science and Technology Nanjing Agricultural University Nanjing 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