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Enzyme hydrolysates were derived from these <jats:styled-content style=\"fixed-case\">PBH<\/jats:styled-content> and the sequence of the A\u03b2 peptide for infusion was selected. The results indicated the <jats:styled-content style=\"fixed-case\">PBH<\/jats:styled-content>, in particular <jats:styled-content style=\"fixed-case\">EP<\/jats:styled-content> (porcine brain extract with ethanol and protease N), demonstrated the potentials to reduce damage of neurodegenerative disorders in\u00a0vitro and in\u00a0vivo. The principal findings of this study indicate that <jats:styled-content style=\"fixed-case\">PBH<\/jats:styled-content> has prolyl endopeptidase inhibitory activity in\u00a0vitro. Moreover, administering <jats:styled-content style=\"fixed-case\">EP<\/jats:styled-content> to A\u03b2(1\u201340)\u2010infused rats significantly improves their performance on reference, spatial performance, and working memory tests during water maze tasks; concurrent proportional decreases are also observed in malondialdehyde levels, acetylcholinesterase (AChE) activity, and A\u03b2 accumulation levels in brain tissues. The <jats:styled-content style=\"fixed-case\">PBH<\/jats:styled-content> was suggested to ameliorate learning deficits associated with Alzheimer's disease by inhibition of lipid peroxidation in the brain of A\u03b2 infused rat.<\/jats:p>","DOI":"10.1111\/asj.13054","type":"journal-article","created":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T02:50:19Z","timestamp":1545187819000},"page":"271-279","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Effects of porcine brain hydrolysate on impairment of cognitive learning ability in amyloid \u03b2<sub>(1\u201340)<\/sub>\u2010infused rats"],"prefix":"10.1111","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9375-5688","authenticated-orcid":false,"given":"Yu\u2010Tse","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Animal Science National Chung Hsing University Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu\u2010Yuan","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Hospitality Management Toko University Chiayi Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6231-2638","authenticated-orcid":false,"given":"Shiro","family":"Takeda","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine Azabu University Sagamihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kung\u2010Ming","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Health Diet and Industrial Management Chung Shan Medical University Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4050-8987","authenticated-orcid":false,"given":"Liang\u2010Chuan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Animal Science National Chung Hsing University Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7425-6119","authenticated-orcid":false,"given":"Ryoichi","family":"Sakata","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine Azabu University Sagamihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2008.02.005"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-013-0036-3"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.03.101"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2010.11.040"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/asj.12509"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-0929.2008.00601.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-0929.2008.00571.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2003.09.004"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.318.7184.615"},{"key":"e_1_2_7_11_1","volume-title":"Method of test for fatty acids in food","author":"Food and Drug Administration","year":"2013"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2015.07.001"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/070674370304800308"},{"key":"e_1_2_7_14_1","first-page":"192","article-title":"Effects of pig brain peptide solution on erythrocuprein and malonaldehyde in senile mice","volume":"9","author":"Han Z. 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