{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T02:49:00Z","timestamp":1787626140907,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,6,29]],"date-time":"2018-06-29T00:00:00Z","timestamp":1530230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Science Journal"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In dairy cows, retained fetal membranes (RFM) affect reproductive performance. The aim of this study was to examine the leukocyte counts and the gene expression of tumour necrosis factor \u03b1 (TNF\u03b1), interleukin 1\u03b2 (IL\u20101\u03b2), IL\u20108, and IL\u201010 in polymorphonuclear leukocytes (PMNs) and peripheral blood mononuclear cells (PBMCs) in cows with (<jats:italic>n<\/jats:italic>\u00a0=\u00a05) or without (<jats:italic>n<\/jats:italic>\u00a0=\u00a05) RFM during the peripartum period. The lymphocyte counts in RFM cows were higher than those in control cows throughout the experiment (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). The expression of IL\u20108 in PMNs of control cows was higher (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05) compared with that of RFM cows postpartum. In cows with RFM, IL\u20101\u03b2 expression was higher (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05) in PMNs at 6\u00a0weeks postpartum whereas the expression of IL\u20101\u03b2 was lower (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05) in PBMCs at 4\u00a0weeks postpartum. The expression of IL\u201010 in PBMCs of control cows was higher (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05) than that of RFM cows at 2\u00a0weeks prepartum and 4\u00a0weeks postpartum. Taken together, our data indicate that changes of gene expression of pro\u2010 and anti\u2010inflammatory cytokines in RFM cows might be associated with the delayed placental separation and development of uterine inflammation in RFM cows.<\/jats:p>","DOI":"10.1111\/asj.13065","type":"journal-article","created":{"date-parts":[[2018,6,29]],"date-time":"2018-06-29T08:48:35Z","timestamp":1530262115000},"page":"1371-1378","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Changes of leukocyte counts and expression of pro\u2010 and anti\u2010inflammatory cytokines in peripheral leukocytes in periparturient dairy cows with retained fetal membranes"],"prefix":"10.1111","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7288-1642","authenticated-orcid":false,"given":"Takashi","family":"Shimizu","sequence":"first","affiliation":[{"name":"Graduate School of Animal and Food Hygiene Obihiro University of Agriculture and Veterinary Medicine Obihiro Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikumi","family":"Morino","sequence":"additional","affiliation":[{"name":"Graduate School of Animal and Food Hygiene Obihiro University of Agriculture and Veterinary Medicine Obihiro Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuji","family":"Kitaoka","sequence":"additional","affiliation":[{"name":"Graduate School of Animal and Food Hygiene Obihiro University of Agriculture and Veterinary Medicine Obihiro Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akio","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Graduate School of Animal and Food Hygiene Obihiro University of Agriculture and Veterinary Medicine Obihiro Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiho","family":"Kawashima","sequence":"additional","affiliation":[{"name":"Field Center of Animal Science and Agriculture Obihiro University of Agriculture and Veterinary Medicine Obihiro Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingo","family":"Haneda","sequence":"additional","affiliation":[{"name":"Department of Clinical Veterinary Science Obihiro University of Agriculture and Veterinary Medicine Obihiro Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8204-2332","authenticated-orcid":false,"given":"Fumie","family":"Magata","sequence":"additional","affiliation":[{"name":"Graduate School of Animal and Food Hygiene Obihiro University of Agriculture and Veterinary Medicine Obihiro Japan"},{"name":"Department of Veterinary Medical Science The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0203082"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anireprosci.2015.02.011"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-2427(94)05302-9"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod46.4.580"},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"3815","DOI":"10.4049\/jimmunol.147.11.3815","article-title":"IL\u201010 inhibits cytokine production by activated macrophages","volume":"147","author":"Fiorentino D. 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