{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T21:38:16Z","timestamp":1784756296386,"version":"3.55.0"},"reference-count":63,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T00:00:00Z","timestamp":1562198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2016A030313378"],"award-info":[{"award-number":["2016A030313378"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Science Journal"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The objective of this experiment was to evaluate the effects of dietary supplementation with porous zinc oxide (HiZox) on growth performance, intestinal microbiota, morphology, and permeability in weaned piglets. A total of 128 weaned piglets [(Landrace\u00a0\u00d7\u00a0Yorkshire)\u00a0\u00d7\u00a0Duroc] with an average body weight (BW) of (6.55\u00a0\u00b1\u00a00.25\u00a0kg; 21\u00a0d of age) were randomly assigned to four dietary treatments: (1) a corn\u2010soybean basal diet; (2) basal diet\u00a0+\u00a03,000\u00a0mg\/kg conventional ZnO; (3) basal diet\u00a0+\u00a0200\u00a0mg\/kg HiZox; (4) basal diet\u00a0+\u00a0500\u00a0mg\/kg HiZox. The experiments lasted for 28\u00a0days. Incremental HiZox in the diet increased ADG (linear <jats:italic>p<\/jats:italic>\u00a0=\u00a00.015; quadratic <jats:italic>p<\/jats:italic>\u00a0=\u00a00.043) and ADFI (linear <jats:italic>p<\/jats:italic>\u00a0=\u00a00.027; quadratic <jats:italic>p<\/jats:italic>\u00a0=\u00a00.038), and the diarrhea index decreased linearly and quadratically (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01) as HiZox supplemented increased. Furthermore, supplementation with HiZox increased the amounts of <jats:italic>Lactobacillus <\/jats:italic>spp. (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) in the ileum and cecum in comparison with that of control treatment or 3,000\u00a0mg\/kg ZnO treatment, while decreased the populations of <jats:italic>Escherichia coli<\/jats:italic>, <jats:italic>Clostridium coccoides<\/jats:italic>, and <jats:italic>Clostridium. leptum<\/jats:italic> sub<jats:italic>group<\/jats:italic> (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) in the ileum and cecum relative to those in control treatment. The addition of HiZox increased the villus height and villus\u2010to\u2010crypt ratio (VC) of duodenum, jejunum, and ileum (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05), while decreased the crypt depth of jejunum (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) and tended to reduce the crypt depth of duodenum (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.10) compared with the control treatment. Piglets fed with 500\u00a0mg\/kg HiZox had lower serum D\u2010lactate and diamine oxidase (DAO) than those fed with basal control diet or 3,000\u00a0mg\/kg ZnO diet (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01). The results suggested that supplementation with HiZox modulated intestinal microbial composition and improved intestinal morphology, which may exert protective effects on the integrity of the mucosal barrier function of weaned piglets, was as efficacious as pharmaceutical doses of ZnO in enhancing growth performance, indicating that the HiZox may be a promising alternative to pharmaceutical doses of ZnO.<\/jats:p>","DOI":"10.1111\/asj.13228","type":"journal-article","created":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T05:28:42Z","timestamp":1562304522000},"page":"1220-1228","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["The effects of dietary supplementation with porous zinc oxide on growth performance, intestinal microbiota, morphology, and permeability in weaned piglets"],"prefix":"10.1111","volume":"90","author":[{"given":"Peng","family":"Peng","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology Hunan Agricultural University Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4474-6803","authenticated-orcid":false,"given":"Jiashun","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Hunan Agricultural University Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Yao","sequence":"additional","affiliation":[{"name":"Institute of Subtropical Agriculture Chinese Academy of Sciences Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulong","family":"Yin","sequence":"additional","affiliation":[{"name":"Institute of Subtropical Agriculture Chinese Academy of Sciences Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Long","sequence":"additional","affiliation":[{"name":"College of Life Science and Engineering Foshan University Foshan Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rejun","family":"Fang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Hunan Agricultural University Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,4]]},"reference":[{"issue":"184","key":"e_1_2_7_2_1","article-title":"Lactobacillus plantarum DSM 2648 is a potential probiotic that enhances intestinal barrier function","volume":"309","author":"Anderson R. 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