{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T17:55:03Z","timestamp":1780595703675,"version":"3.54.1"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,3,23]],"date-time":"2020-03-23T00:00:00Z","timestamp":1584921600000},"content-version":"vor","delay-in-days":82,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Science Journal"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aims of this study were to investigate the effects of dietary supplementation with dihydroartemisinin (DHA) on growth performance, hepatic inflammation, and lipid metabolism in intrauterine growth retardation (IUGR)\u2010affected weaned piglets. Eight piglets with normal birth weight (NBW) and 16 IUGR\u2010affected piglets were selected and fed either a basal diet (NBW and IUGR groups) or the basal diet supplemented with 80\u00a0mg\/kg DHA (IUGR\u2010DHA group) from 21 to 49 day of age. Blood and liver samples were collected on day 49. DHA supplementation significantly alleviated the compromised growth performance and liver damage in IUGR\u2010affected piglets. Additionally, DHA supplementation decreased the activities of alanine aminotransferase and aspartate aminotransferase, as well as the serum levels of non\u2010esterified fatty acids (NEFA), very\u2010low\u2010density lipoprotein, and total cholesterol. In the liver, the concentrations of interleukin 1 beta, interleukin 6, tumor necrosis factor alpha, triglycerides, and NEFA were decreased. Fatty acid synthesis was decreased by DHA supplementation, whereas the activities of lipoprotein lipase, hepatic lipase, and total lipase were increased. Dietary DHA supplementation led to upregulation of the expression of AMPK\/SIRT1 signaling pathway\u2010related genes, whereas that of inflammatory factor\u2010related genes were downregulated. In conclusion, dietary inclusion of 80\u00a0mg\/kg DHA can alleviate IUGR\u2010induced impairments in piglets.<\/jats:p>","DOI":"10.1111\/asj.13363","type":"journal-article","created":{"date-parts":[[2020,3,24]],"date-time":"2020-03-24T04:51:10Z","timestamp":1585025470000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Effects of dietary dihydroartemisinin supplementation on growth performance, hepatic inflammation, and lipid metabolism in weaned piglets with intrauterine growth retardation"],"prefix":"10.1111","volume":"91","author":[{"given":"Yongwei","family":"Zhao","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology Nanjing Agricultural University Nanjing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Niu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Nanjing Agricultural University Nanjing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jintian","family":"He","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Nanjing Agricultural University Nanjing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhending","family":"Gan","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Nanjing Agricultural University Nanjing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuli","family":"Ji","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Nanjing Agricultural University Nanjing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Nanjing Agricultural University Nanjing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Nanjing Agricultural University Nanjing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9038-5009","authenticated-orcid":false,"given":"Tian","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Nanjing Agricultural University Nanjing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/263674"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2009.09.004"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00144.2005"},{"key":"e_1_2_6_5_1","first-page":"97","article-title":"Erratum: Leucine\u2010nicotinic acid synergy stimulates AMPK\/Sirt1 signaling and regulates lipid metabolism and lifespan in Caenorhabditis elegans, and hyperlipidemia and atherosclerosis in mice","volume":"7","author":"Bruckbauer A.","year":"2017","journal-title":"American Journal of Cardiovascular Disease"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep19074"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1101\/157396"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.2527\/jas1986.6261682x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864\u2010016\u20103385\u20108"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114513001232"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0136848"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114518001630"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1mb05024a"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102567.2005.02143.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272\u2010013\u20100150\u20102"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3887571"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2005.07.022"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201012\u20100429"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.5713\/ajas.15.0309"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2006.03.004"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.5713\/ajas.15.0810"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40104\u2010018\u20100236\u20102"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.111.153411"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2012.06.016"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/1745039X.2014.897532"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378\u20103782(14)70014\u20103"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2016.108"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.05.022"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2008.08.001"},{"key":"e_1_2_6_30_1","volume-title":"Nutrient requirements of swine","author":"NRC","year":"2012"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agh074"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612811319150009"},{"key":"e_1_2_6_33_1","first-page":"157396","article-title":"Artemisinin mimics nitric oxide to reduce adipose weight by targeting mitochondrial complexes","volume":"157396","author":"Qian G.","year":"2017","journal-title":"BioRxiv"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.domaniend.2004.06.006"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250\u2010200203000\u201000020"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00745.2009"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/1824\u20107288\u201037\u201041"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.9.2181"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.115.119834"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2008.12.015"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001340051125"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/asj.12766"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10111"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114511006763"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.3109\/08923973.2013.785559"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2007\u20100459"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.113217"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2095\u20103119(13)60262\u20102"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436\u2010014\u20103822\u2010z"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2016.10.498"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2017.04.008"}],"container-title":["Animal Science Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/asj.13363","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/asj.13363","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/asj.13363","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T15:43:49Z","timestamp":1692719029000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/asj.13363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1111\/asj.13363"],"URL":"https:\/\/doi.org\/10.1111\/asj.13363","archive":["Portico"],"relation":{},"ISSN":["1344-3941","1740-0929"],"issn-type":[{"value":"1344-3941","type":"print"},{"value":"1740-0929","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"2019-05-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13363"}}