{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:25:31Z","timestamp":1773015931986,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T00:00:00Z","timestamp":1594771200000},"content-version":"vor","delay-in-days":196,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Science Journal"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recessive missense mutation in the solute carrier family 12, member 1 (<jats:italic>SLC12A1<\/jats:italic>) gene (g.62382825G&gt;A) is associated with hydrallantois, which is the accumulation of fluid in the allantoic cavity of a pregnant animal, and usually causes fetal death in Japanese Black cattle. However, the symptoms of a homozygote with this mutation that do not result in fetal death have not previously been tracked and evaluated. In the present study, we observed a homozygote with the <jats:italic>SLC12A1<\/jats:italic> risk allele over a long\u2010term period. The calf did not show any obvious clinical symptoms, although it did exhibit a slight growth retardation that accompanied mild calciuria. At 28\u00a0months of age, the homozygote showed renal dysfunction, which in turn resulted in hydronephrosis. The time course of the symptoms was consistent with the phenotype of Bartter syndrome in humans. Additionally, the risk heterozygous genotype did not any effects on carcass traits, which indicates that eliminating the risk allele would not have any unfavorable effects. Therefore, we emphasize that both the fetal\u2010 and late\u2010stage symptoms associated with the <jats:italic>SLC12A1<\/jats:italic> risk allele compromise animal welfare, and consequently may result in severe economic losses for individual farmers if the <jats:italic>SLC12A1<\/jats:italic> risk allele is not eliminated from the population.<\/jats:p>","DOI":"10.1111\/asj.13415","type":"journal-article","created":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T03:47:53Z","timestamp":1594871273000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A long\u2010term study of the effects of <i>SLC12A1<\/i> homozygous mutation (g.62382825G&gt;A, p.Pro372Leu) in Japanese Black cattle"],"prefix":"10.1111","volume":"91","author":[{"given":"Yoichi","family":"Sakamoto","sequence":"first","affiliation":[{"name":"Shimane Prefecture Livestock Technology Center Izumo Shimane Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyotoshi","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Matsue Livestock Hygiene Service Center Matsune Shimane Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunsuke","family":"Moriwaki","sequence":"additional","affiliation":[{"name":"Shimane Prefecture Livestock Technology Center Izumo Shimane Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Hara","sequence":"additional","affiliation":[{"name":"Matsue Livestock Hygiene Service Center Matsune Shimane Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuta","family":"Hamada","sequence":"additional","affiliation":[{"name":"Shimane Domestic Livestock Disease Identification Office Izumo Shimane Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1070-2247","authenticated-orcid":false,"given":"Shinji","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Faculty of Agriculture University of the Ryukyus Nishihara Okinawa Japan"},{"name":"United Graduate School of Agricultural Sciences Kagoshima University Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,15]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"45","article-title":"The fetal fluids of domestic animals","volume":"9","author":"Arthur G. 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