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Piglets fed 20.0% CP had greater weight gain and feed intake. Including 12.0% LAC in the 20.0% CP diet provided higher villous height in the duodenum than 8.0% LAC, and 12.0% or 16.0% LAC in the 24.0% CP diet resulted in higher villous height in the jejunum and ileum, and higher villi\/crypt ratio in the ileum than 8.0% LAC. No effects of CP and LAC on interleukin\u20101\u03b2 and tumor necrosis factor\u2010\u03b1 mRNA were observed. The 16.0% LAC diet provided higher gene expression of transforming\u2010\u03b21 growth factor. Feeding 20.0% CP resulted in better performance than 24.0% CP. The 12.0% LAC diet promoted greater genetic expression of occludin and zonula occludens. Including 12.0% LAC in the diet may improve intestinal epithelial morphology and integrity, and these improvements are more evident when piglets are fed diets with 24.0% CP.<\/jats:p>","DOI":"10.1111\/asj.13429","type":"journal-article","created":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T04:22:29Z","timestamp":1595391749000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effects of crude protein and lactose levels in diets on growth performance, intestinal morphology, and expression of genes related to intestinal integrity and immune system in weaned piglets"],"prefix":"10.1111","volume":"91","author":[{"given":"Marcos H.","family":"Soares","sequence":"first","affiliation":[{"name":"Department of Animal Sciences Universidade Federal de Vi\u00e7osa Vi\u00e7osa\u2010MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo A.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences Universidade Federal de Vi\u00e7osa Vi\u00e7osa\u2010MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00edvia M. 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