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Forty\u2010eight Wistar albino rats were equally allocated into four groups: control;\u00a0sidr honey (5g\/kg body weight (BW), orally); TAA (200\u00a0mg\/kg\u00a0BW,\u00a0IP three times\u00a0weekly\/15\u00a0weeks);\u00a0and\u00a0sidr honey\u00a0plus\u00a0TAA at the same dose and administration rout. Rats co\u2010treated with sidr honey\u00a0plus\u00a0TAA revealed significant reduction in hepatic malondialdehyde, hyaluronic acid (HA), alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, gamma glutamyl transferase, direct bilirubin, and hepatic mRNA expression of transforming growth factor (TGF)\u2010\u03b21 and collagen type I alpha 1 chain (COL1a1) compared to TAA\u2010exposed rats. In addition, the hepatoprotective potential of sidr honey was indicated via improvement of histopathologic picture of hepatocytes and upregulation of total antioxidant capacity, reduced glutathione, catalase, glutathione peroxidase, superoxide dismutase, total protein, and albumin compared to TAA\u2010treated rats. In conclusion, daily administration of sidr honey (5\u00a0g\/kg BW) is a promising natural antioxidant and fibrosuppressive\u00a0agent that could ameliorate liver fibrosis via downregulation of fibrosis genes including TGF\u2010\u03b21 and COL1a1 and HA and via enhancement of antioxidant system.<\/jats:p>","DOI":"10.1111\/asj.13434","type":"journal-article","created":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T04:17:41Z","timestamp":1595391461000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Sidr honey abrogates the oxidative stress and downregulates the hyaluronic acid concentration and gene expression of TGF\u2010\u03b21 and COL1a1 in rat model of thioacetamide\u2010induced hepatic fibrosis"],"prefix":"10.1111","volume":"91","author":[{"given":"Mohamed M.","family":"Zeweil","sequence":"first","affiliation":[{"name":"Department of Biochemistry Faculty of Veterinary Medicine Damanhour University Damanhour Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kadry M.","family":"Sadek","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty of Veterinary Medicine Damanhour University Damanhour Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed F.","family":"Elsadek","sequence":"additional","affiliation":[{"name":"Department of Community Health Sciences College of Applied Medical Sciences King Saud University Riyadh Saudi Arabia"},{"name":"Department of Nutrition and Food Science Faculty of Home Economics Helwan University Helwan Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar F.","family":"Mahmoud","sequence":"additional","affiliation":[{"name":"Department of Histology Faculty of Veterinary Medicine Damanhour University Damanhour Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Badreldin M.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Community Health Sciences College of Applied Medical Sciences King Saud University Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4235-669X","authenticated-orcid":false,"given":"Asmaa F.","family":"Khafaga","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Veterinary Medicine Alexandria University Edfina Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.1057"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2008.11.015"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(84)05016-3"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani10040626"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2019.134879"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100037\u20101601350"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2008.01.011"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042\u20107158.1991.tb03186.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0271\u20105317(02)00406\u20102"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.5897\/JMA2012.0235"},{"key":"e_1_2_8_12_1","volume-title":"The honey prescription: The amazing power of honey as medicine: Healing arts press","author":"Altman N.","year":"2010"},{"key":"e_1_2_8_13_1","first-page":"BR433\u2010BR438","article-title":"The antimicrobial potential of honey from United Arab Emirates on some microbial isolates. 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