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However, the chronic effect of microbiota disturbances during prenatal and neonatal developing periods on animal's health remains less studied. In the current study, pregnant ICR mice were fed with an antibiotic diet (7\u2010g nebacitin [bacitracin\u2010neomycin sulphate 2:1]\/kg standard diet) from day 14 of conception, and their offspring were provided with the same diet till the termination of the experiments. Dams treated with antibiotics showed increased body weight along with enlarged gut. Antibiotic\u2010treated offspring revealed decreased bodyweight, increased food, water, and sucrose intake. Administration of antibiotics affected corticosterone responsivity to acute 20\u00a0min restraint challenge in male pups. In behavior tests, female pups showed decreased movement in open field while male pups revealed decreased latency to open arms in elevated plus maze test and immobility time in tail suspension test. Together, these results suggested that early antibiotic exposure may impact on the food intake, body weight gain, and emotional behavior regulation in mice.<\/jats:p>","DOI":"10.1111\/asj.13566","type":"journal-article","created":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T07:02:03Z","timestamp":1624604523000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Dysregulated metabolism and behaviors by disrupting gut microbiota in prenatal and neonatal mice"],"prefix":"10.1111","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3685-4062","authenticated-orcid":false,"given":"Guofeng","family":"Han","sequence":"first","affiliation":[{"name":"Laboratory of Regulation in Metabolism and Behavior Department of Bioresource Sciences Graduate School of Bioresource and Bioenvironmental Sciences Kyushu University Fukuoka Japan"},{"name":"Department of Animal Nutrition and Food Science College of Animal 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