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Thus, the normal function of ruminal epithelium is critical for ruminants. However, subacute ruminal acidosis induced by high\u2010concentrate diets often damages the barrier function of ruminal epithelium in ruminants. Recently, many studies have shown that dietary supplementation with thiamine is an effective method to alleviate subacute ruminal acidosis. In order to provide theoretical reference for the in\u2010depth study of subacute ruminal acidosis and the application of thiamine in the future, this review introduces the effects of subacute ruminal acidosis on morphological structure, inflammatory response, and tight junction of ruminal epithelium. In addition, this paper summarizes the role of thiamine in maintaining ruminal epithelial function of ruminants during subacute ruminal acidosis challenge.<\/jats:p>","DOI":"10.1111\/asj.13579","type":"journal-article","created":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T00:34:02Z","timestamp":1624667642000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Potential protective effects of thiamine supplementation on the ruminal epithelium damage during subacute ruminal acidosis"],"prefix":"10.1111","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6979-5070","authenticated-orcid":false,"given":"Jian","family":"Ma","sequence":"first","affiliation":[{"name":"Low Carbon Breeding Cattle and Safety Production University Key Laboratory of Sichuan Province, Animal Nutrition Institute Sichuan Agricultural University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Mujtaba","family":"Shah","sequence":"additional","affiliation":[{"name":"Low Carbon Breeding Cattle and Safety Production University Key Laboratory of Sichuan Province, Animal Nutrition Institute Sichuan Agricultural University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhisheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Low Carbon Breeding Cattle and Safety Production University Key Laboratory of Sichuan Province, Animal Nutrition Institute Sichuan Agricultural University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Fan","sequence":"additional","affiliation":[{"name":"College of Animal Science Xinjiang Agricultural University  Urumchi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0921\u20104488(98)00188\u20106"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2015\u201010521"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2016\u201011274"},{"key":"e_1_2_8_5_1","volume-title":"Effects of thiamine on the metabolism of the rumen and its consequences to subacute ruminal acidosis in goats","author":"Dong S. 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