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Results showed that APPs improved jejunal barrier function by increasing the villus height, villus height\/crypt depth, the mRNA levels of\n                    <jats:italic>occludin<\/jats:italic>\n                    ,\n                    <jats:italic>mucin\u20101<\/jats:italic>\n                    , and\n                    <jats:italic>mucin\u20104<\/jats:italic>\n                    and up\u2010regulating the protein expression of occluding (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05). As for antioxidant capacity, APPs increased the activities of total superoxide dismutase and glutathione peroxidase and total antioxidant capacity level in jejunum (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05). Besides, APPs up\u2010regulated the protein expressions of NAD(P)H quinone dehydrogenase 1 (NQO1), heme oxygenase\u20101 (HO\u20101), and nuclear\u2010related factor 2 (NRF2) and down\u2010regulated the protein expression of kelch\u2010like ECH\u2010associated protein 1 (Keap1). As regard to immune and inflammatory response, APPs increased the immunoglobulin A content in serum and decreased the mRNA levels of\n                    <jats:italic>tumor necrosis factor\u2010\u03b1<\/jats:italic>\n                    (\n                    <jats:italic>TNF\u2010\u03b1<\/jats:italic>\n                    ),\n                    <jats:italic>interleukin<\/jats:italic>\n                    (\n                    <jats:italic>IL<\/jats:italic>\n                    )\n                    <jats:italic>\u20101\u03b2<\/jats:italic>\n                    ,\n                    <jats:italic>toll\u2010like receptor 4<\/jats:italic>\n                    (\n                    <jats:italic>TLR4<\/jats:italic>\n                    ),\n                    <jats:italic>nuclear factor\u2010\u03baB<\/jats:italic>\n                    (\n                    <jats:italic>NF\u2010\u03baB<\/jats:italic>\n                    ), and\n                    <jats:italic>IL\u20108<\/jats:italic>\n                    in jejunum (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05). Overall, dietary APPs supplementation improves the jejunal barrier function by enhancing antioxidant capacity and suppressing the mRNA expression related to inflammation, which may be related to the NRF2 signal and TLR4\/NF\u2010\u03baB signal.\n                  <\/jats:p>","DOI":"10.1111\/asj.13747","type":"journal-article","created":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T10:28:49Z","timestamp":1655202529000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Apple polyphenols improve intestinal barrier function by enhancing antioxidant capacity and suppressing inflammation in weaning piglets"],"prefix":"10.1111","volume":"93","author":[{"given":"Zhongyang","family":"Guo","sequence":"first","affiliation":[{"name":"Key Laboratory for Animal Disease\u2010Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition Sichuan Agricultural University  Chengdu 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