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Therefore, epithelial innate immunity, including antimicrobial peptides\/proteins (AMPs), is important during the early stage of their lives. Chemerin, a multifunctional protein that was originally identified as a chemokine, possesses a potent antimicrobial activity. The present study investigated the expression levels of chemerin in the gastrointestinal (GI) tract of growing calves. Chemerin and its coding gene, retinoic acid receptor responder protein 2 (<jats:italic>RARRES2<\/jats:italic>), were highly expressed in duodenum, jejunum, and ileum compared with other parts of the GI tract. Immunohistochemistry demonstrated that chemerin\u2010producing cells were localized in the crypt of the intestinal mucosa. Finally, the expression level of <jats:italic>RARRES2<\/jats:italic> was higher compared with those of other major AMPs in duodenum, although it was lower compared with that of enteric \u03b2\u2010defensin but mostly higher than those of other AMPs in jejunum and ileum at various ages in calves. The expression levels of <jats:italic>RARRES2<\/jats:italic> were not influenced by the age of calves in duodenum and jejunum, whereas a higher expression level of <jats:italic>RARRES2<\/jats:italic> in ileum was observed in younger calves. This study revealed that chemerin is produced in the small intestine of calves and has the potential to contribute to the gut epithelial barrier system.<\/jats:p>","DOI":"10.1111\/asj.13750","type":"journal-article","created":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T05:55:30Z","timestamp":1656654930000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Expression of chemerin in intestinal mucosa of calves with comparable expression level with other antimicrobial proteins"],"prefix":"10.1111","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0768-2548","authenticated-orcid":false,"given":"Yutaka","family":"Suzuki","sequence":"first","affiliation":[{"name":"Graduate School of Agriculture Hokkaido University  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanako","family":"Kubota","sequence":"additional","affiliation":[{"name":"Graduate School of Agriculture 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