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Herein, this study was performed to investigate the expression changes related to nutrient sensing and transport in the ileal and colonic epithelium of goats in response to feeding an HG diet. Twelve Liuyang black goats (similar age and weight) were randomly assigned into two groups: an HG diet (concentrate: hay\u2009=\u200990:10) and a CON diet (concentrate: hay\u2009=\u200955:45). Immunohistochemistry was applied to detect morphological changes in the gut epithelium together with altered expression of chemosensors in the ileum and colon. The results showed that feeding an HG diet increased ileal villus height and depth and induced mucosal sloughing in the colon. The expressions of the nutrient transporters GLUT2, GLUT5, SGLT2, CD36, rBAT, EAAT3, and LAT2 and sensing receptors GPR43 and T1R1 were promoted in the ileum under HG conditions. Moreover, feeding an HG diet also enhanced the expression of GLUT2, SGLT2, CD36, and GPR43 in the colon. These findings indicate that adaptation of the gastrointestinal tract to the HG diet promoted the absorption of glucose, fatty acids, and amino acids in goats.<\/jats:p>","DOI":"10.1111\/asj.13754","type":"journal-article","created":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T08:19:07Z","timestamp":1657095547000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The expression of nutrient chemosensing gate molecules in the ileum and colon is altered for goats fed on a high\u2010grain diet"],"prefix":"10.1111","volume":"93","author":[{"given":"Changxin","family":"Tian","sequence":"first","affiliation":[{"name":"CAS Key Laboratory of Agro\u2010ecological Processes in Subtropical Region, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, Institute of Subtropical Agriculture The Chinese Academy of Sciences  Changsha P. R. China"},{"name":"University of Chinese Academy of Sciences  Beijing P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Wu","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Agro\u2010ecological Processes in Subtropical Region, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, Institute of Subtropical Agriculture The Chinese Academy of Sciences  Changsha P. R. China"},{"name":"University of Chinese Academy of Sciences  Beijing P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinzhen","family":"Jiao","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Agro\u2010ecological Processes in Subtropical Region, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, Institute of Subtropical Agriculture The Chinese Academy of Sciences  Changsha P. R. 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China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiliang","family":"Tan","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Agro\u2010ecological Processes in Subtropical Region, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, Institute of Subtropical Agriculture The Chinese Academy of Sciences  Changsha P. R. 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