{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T16:14:38Z","timestamp":1769357678093,"version":"3.49.0"},"reference-count":54,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,24]],"date-time":"2022-10-24T00:00:00Z","timestamp":1666569600000},"content-version":"vor","delay-in-days":296,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Science Journal"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Heat stress impacts the immune system of dairy animals by altering the hypothalamic\u2013pituitary\u2013adrenal axis and thyroid function, leading to conditions such as hypothyroidism and hypercortisolism. This study aimed to elucidate the effect of hypothyroidism and hypercortisolism on the response of mammary innate immune function to inflammation caused by <jats:styled-content style=\"fixed-case\"><jats:italic>Escherichia coli<\/jats:italic><\/jats:styled-content> in dairy goats. To induce hypothyroidism and hypercortisolism, we administered 6\u2010n\u2010propyl\u20102\u2010thiouracil (PTU; for 21\u2009days) and dexamethasone (DEX; for 5\u00a0days), respectively, to six goats each; six goats without treatment were used as the control group. After treatment, lipopolysaccharide (LPS) from <jats:styled-content style=\"fixed-case\"><jats:italic>E.\u2009coli<\/jats:italic><\/jats:styled-content> O111 was infused into the mammary gland. Somatic cell counts (SCC) and levels of lactoferrin (LF), S100A7, immunoglobulin A (IgA), and interleukin\u20108 (IL\u20108) in milk until 7\u00a0days after LPS infusion were measured. An increase in SCC after LPS infusion was inhibited in both PTU and DEX groups, and an increase in LF after LPS infusion was inhibited in PTU group, compared with that in the control group. The results of the present study suggest that the recruitment of neutrophils and LF production decreased under hypothyroidism or hypercortisolism, which may be one of the causes underlying increased incidence of mastitis in dairy animals under heat stress conditions.<\/jats:p>","DOI":"10.1111\/asj.13773","type":"journal-article","created":{"date-parts":[[2022,10,24]],"date-time":"2022-10-24T07:35:31Z","timestamp":1666596931000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Effect of 6\u2010n\u2010propyl\u20102\u2010thiouracil or dexamethasone administration on the responses of antimicrobial components in goat milk to intramammary lipopolysaccharide infusion"],"prefix":"10.1111","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6045-6729","authenticated-orcid":false,"given":"Naoki","family":"Suzuki","sequence":"first","affiliation":[{"name":"Graduate school of Integrated Sciences for Life Hiroshima University, Higashi\u2010Hiroshima  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fika Yuliza","family":"Purba","sequence":"additional","affiliation":[{"name":"Veterinary Medicine Study Program, Faculty of Medicine Hasanuddin University  Makassar Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Nii","sequence":"additional","affiliation":[{"name":"Graduate school of Integrated Sciences for Life Hiroshima University, Higashi\u2010Hiroshima  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9230-6346","authenticated-orcid":false,"given":"Naoki","family":"Isobe","sequence":"additional","affiliation":[{"name":"Graduate school of Integrated Sciences for Life Hiroshima University, Higashi\u2010Hiroshima  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.327545"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2019.08.011"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0192-0561(94)00088-6"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2527\/1999.77102749x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2007.04.026"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1051\/vetres:2003023"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.5b01836"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2017.04.003"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-32886-1"},{"key":"e_1_2_6_11_1","first-page":"7","article-title":"Manipulating thyroid status alters endoplasmic reticulum calcium homeostasis in rat cerebellum","volume":"50","author":"Cole J. 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