{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:12:42Z","timestamp":1791839562153,"version":"4.3.4"},"reference-count":76,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T00:00:00Z","timestamp":1679270400000},"content-version":"vor","delay-in-days":78,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP19H03110"],"award-info":[{"award-number":["JP19H03110"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP21H02344"],"award-info":[{"award-number":["JP21H02344"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP17KT0077"],"award-info":[{"award-number":["JP17KT0077"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP18K19721"],"award-info":[{"award-number":["JP18K19721"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP15K07694"],"award-info":[{"award-number":["JP15K07694"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Science Journal"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>With global warming becoming of increasing concern, poultry farms are experiencing a concomitant increase in heat stress. Chickens are very sensitive to high ambient temperature (HT), so the development of novel nutrients that will help deal with the challenge posed by heat stress is vital. We revealed that L\u2010citrulline (L\u2010Cit) can reduce body temperature in chickens. Orally administered L\u2010Cit solution has been found to provide heat tolerance in chickens and to result in reduced food intake. Heat exposure and oral administration of L\u2010Cit led to increased levels of plasma insulin, whereas heat stress led to a decline in plasma thyroxine. Dietary administration of L\u2010Cit was also shown to be effective to reduce heat stress in broiler chickens. Moreover, L\u2010Cit was found to be metabolized in the liver within 1\u00a0h of its administration, and in L\u2010Cit\u2010treated broiler chicks, the Cit\u2010Arginine cycle and the Krebs cycle were found to be active. L\u2010Cit has not yet been approved for inclusion in the poultry diet, so it is important to find alternative sources of L\u2010Cit. Taken together, these findings suggest that L\u2010Cit may serve as an important novel nutrient with the ability to produce heat tolerance in chickens under HT.<\/jats:p>","DOI":"10.1111\/asj.13826","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T09:12:12Z","timestamp":1679303532000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["L\u2010Citrulline: A novel hypothermic amino acid promoting thermotolerance in heat\u2010exposed chickens"],"prefix":"10.1111","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6709-2788","authenticated-orcid":false,"given":"Vishwajit S.","family":"Chowdhury","sequence":"first","affiliation":[{"name":"Division for Experimental Natural Science, Faculty of Arts and Science, Department of Animal and Marine Bioresource Science, Graduate School of Bioresource and Bioenvironmental Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4565(79)90009-3"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2006.02.005"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2009.12.011"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1071\/AR9911385"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ps\/82.10.1580"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.205.15.2267"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/00071669888511"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.2141\/jpsa.0180024"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtherbio.2017.07.007"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fanim.2022.875572"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/asj.13578"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/asj.13609"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.2141\/jpsa.0150014"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2013.12.020"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.2141\/jpsa.011071"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00478.2002"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-005-0235-4"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1079\/9781845932589.0132"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ps\/82.2.267"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/00071668.2012.719148"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2006.16.25"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.domaniend.2005.02.008"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.domaniend.2005.02.028"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/00071668.2017.1335858"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpb.2004.09.010"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2022.175092"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo12010083"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2014.05.015"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0016-6480(03)00094-7"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-008-0164-0"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2009.05.036"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M404866200"},{"key":"e_1_2_11_34_1","unstructured":"Hennessy K. Lawrence J. &Mackey B.(2022).IPCC Sixth Assessment Report (AR6): Climate Change 2022 \u2010 Impacts Adaptation and Vulnerability: Regional Factsheet Australasia. Retrieved from.https:\/\/policycommons.net\/artifacts\/2264302\/ipcc_ar6_wgii_factsheet_australasia\/3023355\/on 02 Dec 2022. CID: 20.500.12592\/7f1fm4."},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(91)90281-r"},{"key":"e_1_2_11_36_1","first-page":"41","article-title":"Food deprivation and hypothermia in desynchronized sleep deprived rats","volume":"29","author":"Hoshino K.","year":"1996","journal-title":"Brazilian Journal of Medical and Biological Research"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1033.2003.03559.x"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2015.04.010"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/00071668.2014.957653"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-6480(81)90056-3"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2010.10.076"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1179\/147683010X12611460763481"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.2307\/3677259"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1079\/WPS200585"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtherbio.2006.01.002"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12079-017-0397-3"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1997.272.6.R1691"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-6480(89)90130-5"},{"key":"e_1_2_11_49_1","article-title":"Studies with thyroxine and triiodothyronine in chickens","volume":"37","author":"Mellen W. J.","year":"1958","journal-title":"Poultry Science"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps.0410134"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/ps\/76.3.472"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-32041-w"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.2141\/jpsa.0190054"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/327524a0"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291x(86)90034-3"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(91)90521-o"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1017\/s1751731111002448"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00668.2006"},{"key":"e_1_2_11_59_1","first-page":"S36","article-title":"Effect of temperature on the responses of broiler chickens to dietary lysine balance","volume":"38","author":"Rose S. P.","year":"1997","journal-title":"British Poultry Science"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2000.00417.x"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1159\/000017468"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.5713\/ajas.2006.1206"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0396.2009.00951.x"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(96)00159-1"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2004.02.055"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devbrainres.2005.03.004"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(63)90178-4"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.2141\/jpsa.0180136"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psj.2021.101669"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtherbio.2022.103227"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199210000-00019"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0301-0082(00)00056-3"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps.2011-01353"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1981.241.6.E473"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/128.8.1249"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3360001"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps.0750402"}],"container-title":["Animal Science Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/asj.13826","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/asj.13826","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/asj.13826","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T10:04:45Z","timestamp":1704967485000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/asj.13826"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":76,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1111\/asj.13826"],"URL":"https:\/\/doi.org\/10.1111\/asj.13826","archive":["Portico"],"relation":{},"ISSN":["1344-3941","1740-0929"],"issn-type":[{"value":"1344-3941","type":"print"},{"value":"1740-0929","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"2022-12-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13826"}}