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We investigated the changes in population structure among generations at a genome\u2010wide scale and the selected loci across the genome by comparing the observed and expected allele frequency changes in mycoplasma pneumonia of swine (MPS)\u2010selected pigs. Eight hundred and seventy\u2010four Landrace pigs, selected for MPS resistance without reducing average daily gain over five generations, had 37,299 single nucleotide polymorphisms (SNPs) and were used for genomic analyses. Regarding population structure, individuals in the first generation were the most widely distributed and then converged into a specific group, as they were selected over five generations. For allele frequency changes, 96 and 14 SNPs had higher allele frequency changes than the 99.9% and 99.99% thresholds of the expected changes, respectively. These SNPs were evenly spread across the genome, and a few of these selected regions overlapped with previously detected quantitative trait loci for MPS and immune\u2010related traits. Our results indicated that the considerable changes in allele frequency were identified in many regions across the genome by closed\u2010pig line breeding based on estimated breeding value.<\/jats:p>","DOI":"10.1111\/asj.13827","type":"journal-article","created":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T05:22:50Z","timestamp":1680153770000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Genome\u2010wide detection of changes in allelic frequency in Landrace pigs selected for resistance to mycoplasma pneumonia of swine"],"prefix":"10.1111","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2569-9535","authenticated-orcid":false,"given":"Yoshinobu","family":"Uemoto","sequence":"first","affiliation":[{"name":"Graduate School of Agricultural Science Tohoku University Sendai Miyagi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kasumi","family":"Ichinoseki","sequence":"additional","affiliation":[{"name":"Graduate School of Agricultural Science Tohoku University Sendai Miyagi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshimi","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Institute of Agrobiological Sciences National Agriculture and Food Research Organization (NARO) Tsukuba Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nozomi","family":"Oka","sequence":"additional","affiliation":[{"name":"Miyagi Prefecture Animal Industry Experiment Station Osaki Miyagi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironori","family":"Takamori","sequence":"additional","affiliation":[{"name":"Miyagi Prefecture Animal Industry Experiment Station Osaki Miyagi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Kadowaki","sequence":"additional","affiliation":[{"name":"Miyagi Prefecture Animal Industry Experiment Station Osaki Miyagi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chihiro","family":"Shibata","sequence":"additional","affiliation":[{"name":"Miyagi Prefecture Animal Industry Experiment Station Osaki Miyagi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eisaku","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Miyagi Prefecture Animal Industry Experiment Station Osaki Miyagi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4691-4436","authenticated-orcid":false,"given":"Toshihiro","family":"Okamura","sequence":"additional","affiliation":[{"name":"Institute of Livestock and Grassland Science NARO Tsukuba Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5114-4651","authenticated-orcid":false,"given":"Hisashi","family":"Aso","sequence":"additional","affiliation":[{"name":"Graduate School of Agricultural Science Tohoku University Sendai Miyagi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4586-5553","authenticated-orcid":false,"given":"Haruki","family":"Kitazawa","sequence":"additional","affiliation":[{"name":"Graduate School of Agricultural Science Tohoku University Sendai Miyagi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9198-6666","authenticated-orcid":false,"given":"Masahiro","family":"Satoh","sequence":"additional","affiliation":[{"name":"Graduate School of Agricultural Science Tohoku University Sendai Miyagi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3899-9580","authenticated-orcid":false,"given":"Hirohide","family":"Uenishi","sequence":"additional","affiliation":[{"name":"Institute of Agrobiological Sciences National Agriculture and Food Research Organization (NARO) Tsukuba Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3647-2301","authenticated-orcid":false,"given":"Keiichi","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Graduate School of Agricultural Science Tohoku University Sendai Miyagi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,3,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg700"},{"key":"e_1_2_6_3_1","volume-title":"The mathematical theory of quantitative genetics","author":"Blumer M. 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