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If the energy supplied to the cow's body cannot meet its needs, a negative energy balance ensues, and the direct response is fat mobilization. Nicotinamide (NAM) has been reported to reduce the nonesterified fatty acid concentration of postpartum plasma. To study the biochemical adaptations underlying this physiologic dysregulation, 12 dairy cows were sequentially assigned to a NAM (45\u2009g\/day) treatment or control group. Blood samples were collected on day (D) 1 and D21 relative to parturition. Changes to the plasma lipid metabolism of dairy cows in the two groups were compared using lipidomics. There were significant increases in plasma sphingomyelins d18:1\/18:0, d18:1\/23:0, d18:1\/24:1, d18:1\/24:0, and d18:0\/24:0 in the NAM group on D1 relative to parturition. In addition, fatty acids 18:2, 18:1, 18:0, 16:1, and 16:0 were obviously decreased on D21 relative to calving. This research has provided insights into how NAM supplementation improves lipid metabolism in perinatal dairy cows.<\/jats:p>","DOI":"10.1111\/asj.13857","type":"journal-article","created":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T23:39:45Z","timestamp":1690414785000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Nicotinamide supplementation alters plasma lipidomic profiles of peripartal dairy cows"],"prefix":"10.1111","volume":"94","author":[{"given":"Yan","family":"Huang","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine Northwest A&amp;F University  Xianyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijie","family":"Cui","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Northwest A&amp;F University  Xianyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoshi","family":"Wei","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Northwest A&amp;F University  Xianyang China"},{"name":"College of Animal Science and Technology, College of Veterinary Medicine Zhejiang A&amp;F University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayu","family":"Wang","sequence":"additional","affiliation":[{"name":"Lipidall Technologies Company Limited  Changzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhu","family":"Yao","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Northwest A&amp;F University  Xianyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanjiang","family":"Cai","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Northwest A&amp;F University  Xianyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2273-2539","authenticated-orcid":false,"given":"Jianguo","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Northwest A&amp;F University  Xianyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0103412"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-007-9592-5"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/s0007114514002517"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.s0022-0302(99)75474-3"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/20406223221077958"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20283"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.48.113006.094746"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nu.03.070183.001445"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-015-0565-8"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-6148-10-122"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anifeedsci.2005.08.003"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(90)78975-8"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.13209"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16359-9"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2013-7662"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.11190"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molp.2020.07.016"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-019-05136-4"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m510660200"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemphyslip.2018.09.010"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2011-4304"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2012-5646"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114508043377"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2019.108224"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203312462756"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2006-904"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2007-0146"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13103532"},{"key":"e_1_2_8_30_1","volume-title":"Veterinary medicine: A text book of the diseases of cattle, horses, sheep, pigs and goats","author":"Radostits O. 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