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This test adopts a 2\u00a0\u00d7\u20092 factors design, a total of 288 one\u2010day\u2010old male AA broiler chicks randomly allocated to four groups, consisting of six replicates of 12 birds each, which was then denoted as CON group, diquat (DIQ) group (16 mg\/kg BW diquat was injected into birds at the age of 21\u2009days), magnolol (MAG) group (basic bird diet supplemented with 300\u2009mg\/kg magnolol), and MAG\u2009+\u2009DIQ group. At 21\u2009days of age, broilers in the DIQ group and the MAG\u2009+\u2009DIQ group were intraperitoneally injected with 16\u2009mg\/kg BW diquat. Results showed that diet supplementing with MAG could alleviate the decrease of ADG to a certain extent after exposure to DIQ. Addition of magnolol to the diet alleviated the decrease of ADG during injection, antioxidant enzymes, and gene expression and increased the markers of oxidative damage induced by diquat induction. Magnolol supplement reversed the increase of apoptotic cells in the diquat\u2010induced chicken jejunum. RNA sequencing showed that PI3K\u2013Akt, calcium, and NF\u2010kappa B signaling pathways were the main enrichment pathways between the DIQ group and the MAG\u2009+\u2009DIQ group. Our findings revealed that magnolol may improve antioxidant enzyme activity and expression of related genes through the PI3K\u2013Akt pathway to alleviate oxidative stress.<\/jats:p>","DOI":"10.1111\/asj.13891","type":"journal-article","created":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T11:20:32Z","timestamp":1702466432000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Magnolol supplementation alleviates diquat\u2010induced oxidative stress via PI3K\u2013Akt in broiler chickens"],"prefix":"10.1111","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5116-4094","authenticated-orcid":false,"given":"Wei\u2010Shi","family":"Peng","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology Hunan Agricultural University  Changsha China"},{"name":"Hunan Engineering Research Center of Poultry Production Safety  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Gao","sequence":"additional","affiliation":[{"name":"Bright Farming Co., Ltd.  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Feng","family":"Yao","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Hunan Agricultural University  Changsha China"},{"name":"Hunan Engineering Research Center of Poultry Production Safety  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue\u2010Yue","family":"Tong","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Hunan Agricultural University  Changsha China"},{"name":"Hunan Engineering Research Center of Poultry Production Safety  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai\u2010Han","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Hunan Agricultural University  Changsha China"},{"name":"Hunan Engineering Research Center of Poultry Production Safety  Changsha 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