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However, little is known about the protective effects of puerarin on the oxidized oil\u2010induced injury. Here, we describe the anti\u2010inflammatory effects of puerarin in chickens. A total of 360 broilers were arranged in four treatments. Diets included two types of soybean oil (fresh or oxidized) and two levels of puerarin (0 or 750\u2009mg\/kg). Results showed that puerarin alleviated oxidized soybean oil\u2010induced intestinal immune injury by decreasing the expressions of <jats:italic>HSP<\/jats:italic> and pro\u2010inflammatory factor (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) and enhancing the mRNA levels of anti\u2010inflammatory factor and <jats:italic>CATH\u20101<\/jats:italic> (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) in broilers. Moreover, puerarin supplementation decreased the mRNA abundances of <jats:italic>TLR4<\/jats:italic> and <jats:italic>MyD88<\/jats:italic> (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) and upregulated the expressions of <jats:italic>A20<\/jats:italic> and <jats:italic>SOCS\u20101<\/jats:italic> (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) in the small intestine of oxidized soybean oil\u2010challenged broilers. Collectively, this study demonstrates puerarin may be a potential nutrient supplement in the treatment of oxidized oil\u2010induced damage in poultry.<\/jats:p>","DOI":"10.1111\/asj.13895","type":"journal-article","created":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T04:40:46Z","timestamp":1701319246000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Dietary puerarin supplementation improves immune function in the small intestines of oxidized oil\u2010challenged broilers"],"prefix":"10.1111","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2581-4276","authenticated-orcid":false,"given":"Hua","family":"Zhou","sequence":"first","affiliation":[{"name":"Jiangxi Province Key Laboratory of Animal Nutrition, College of Animal Science and Technology Jiangxi Agricultural University  Nanchang China"},{"name":"Jiangxi Province Key Innovation Center of Integration in Production and Education for High\u2010quality and Safe Livestock and Poultry  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingmei","family":"Yu","sequence":"additional","affiliation":[{"name":"Jiangxi Province Key Laboratory of Animal Nutrition, College of Animal Science and Technology Jiangxi Agricultural University  Nanchang China"},{"name":"Jiangxi Province Key Innovation Center of Integration in Production and Education for High\u2010quality and Safe Livestock and Poultry  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Shi","sequence":"additional","affiliation":[{"name":"Jiangxi Province Key Laboratory of Animal Nutrition, College of Animal Science and Technology Jiangxi Agricultural University  Nanchang China"},{"name":"Jiangxi Province Key Innovation Center of Integration in Production and Education for High\u2010quality and Safe Livestock and Poultry  Nanchang 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