{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T09:50:48Z","timestamp":1769334648434,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"vor","delay-in-days":283,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100017668","name":"Anhui Provincial Key Research and Development Plan","doi-asserted-by":"publisher","award":["202204c06020076"],"award-info":[{"award-number":["202204c06020076"]}],"id":[{"id":"10.13039\/501100017668","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Science Journal"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ochratoxin A (OTA) widely exists in raw food and feed materials and can induce liver damage and toxicity. However, the mechanisms of OTA\u2010induced hepatotoxicity were largely unknown. Thus, our study aimed to uncover the vital genes relevant to OTA\u2010induced hepatotoxicity in broiler chickens. Gene expression data of chicken embryo primary hepatocytes (CEPHs) in OTA\u2010treated and control groups were obtained from the GEO database. Totally 1407 differentially expressed genes (DEGs) were selected, of which 850 and 557 genes were up\u2010 and downregulated in OTA\u2010treated CEPHs. Gene ontology (GO) enrichment revealed that the DEGs were in connection with various biological processes, such as signal transduction, extracellular matrix organization, axon guidance, cell division, cholesterol homeostasis, proteolysis, microtubule cytoskeleton organization, and chromosome segregation. Pathway enrichment showed that the DEGs were related to metabolic pathways, ferroptosis, calcium, FoxO, Wnt, cell cycle, apoptosis, calcium, and cell adhesion molecules signaling pathways. Furthermore, the hub genes, including <jats:italic>CDK1, DLGAP5, KIF2C, VCL, ITGB3,<\/jats:italic> and <jats:italic>ZYX<\/jats:italic>, were identified as hub genes potentially contributing to OTA\u2010induced hepatotoxicity. Taken together, this study provides valuable insights into the mechanisms underlying OTA\u2010induced hepatotoxicity in broiler chickens.<\/jats:p>","DOI":"10.1111\/asj.14005","type":"journal-article","created":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T02:31:59Z","timestamp":1728613919000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Unveiling the hub genes associated with ochratoxin A\u2010induced hepatotoxicity in broiler chickens"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0563-3694","authenticated-orcid":false,"given":"Xiaofeng","family":"Li","sequence":"first","affiliation":[{"name":"College of Animal Science Anhui Science and Technology University  Fengyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Animal Science Anhui Science and Technology University  Fengyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shujuan","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Animal Science Anhui Science and Technology University  Fengyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7657-2158","authenticated-orcid":false,"given":"Bing","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Animal Science Anhui Science and Technology University  Fengyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgp049"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.32604\/or.2023.029549"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2021.12914"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2011.01.001"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.647353"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/2061024"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-003-0804-4"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1556\/004.2024.01016"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-05452-x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-022-00547-9"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs-19479\/v1"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0080789"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11213368"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105838"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1247\/csf.27.39"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13225673"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11756-021-00691-3"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b20-00282"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2018.08.026"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32010"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-44305-0"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800626"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2020.04.094"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-020-00766-y"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M410844200"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2021.125239"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2023.121362"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2018.9285"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psj.2019.10.041"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins14090628"}],"container-title":["Animal Science Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/asj.14005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T01:37:33Z","timestamp":1735263453000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/asj.14005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/asj.14005"],"URL":"https:\/\/doi.org\/10.1111\/asj.14005","archive":["Portico"],"relation":{},"ISSN":["1344-3941","1740-0929"],"issn-type":[{"value":"1344-3941","type":"print"},{"value":"1740-0929","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"2024-03-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14005"}}