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One hundred sixty nursery pigs (6.0\u2009\u00b1\u20091.6\u2009kg BW) were assigned to four treatments arranged in a 2\u2009\u00d7\u20092 factor: antibiotic use and \u03b2\u2010glucan supplementation (0.02% Algamune). Diets were fed for 5 weeks, at which eight pigs from each treatment were selected for tissue sample collection. During the overall experimental period, antibiotics improved (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) ADG and G:F. In Week 5, \u03b2\u2010glucan supplementation increased (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) the ADG of pigs without antibiotics, whereas \u03b2\u2010glucan supplementation had no effect in pigs with antibiotics. In Phase 3, \u03b2\u2010glucan supplementation tended to increase (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.061) ADFI of pigs without antibiotics, whereas \u03b2\u2010glucan supplementation had no effect in pigs with antibiotics. Both antibiotics and \u03b2\u2013glucan increased (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) villus height in the duodenum. Supplementation of \u03b2\u2013glucan reduced (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) IgA in the jejunum and tended to reduce (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.053) IgA in the ileum. In conclusion, \u03b2\u2013glucan from microalgae may encourage growth and feed intake of nursery pigs by improving intestinal health when antibiotics are not used in the diets.\n                  <\/jats:p>","DOI":"10.1111\/asj.70056","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T23:19:11Z","timestamp":1745277551000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy of \u03b2\u2013Glucan From Microalgae on the Intestinal Health and Growth of Nursery Pigs"],"prefix":"10.1111","volume":"96","author":[{"given":"Naiana\u00a0E.","family":"Manzke","sequence":"first","affiliation":[{"name":"Department of Animal Science North Carolina State University  Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexa\u00a0R.","family":"Gormley","sequence":"additional","affiliation":[{"name":"Department of Animal Science North Carolina State University  Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young\u00a0Ihn","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Animal Science North Carolina State University  Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanpuech","family":"Parnsen","sequence":"additional","affiliation":[{"name":"Department of Animal Science North Carolina State University  Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4591-1943","authenticated-orcid":false,"given":"Sung\u00a0Woo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Animal Science North Carolina State University  Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.107.133124"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.5713\/ajas.2013.13411"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2012.11.001"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.livsci.2019.02.018"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dci.2014.10.005"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jas\/skae206"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-818305-2.00004-8"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008105416065"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.algal.2017.04.008"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23063156"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.2527\/jas1988.662574x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2010\u20103005"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani12223141"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani13132236"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2024.106182"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.livsci.2007.01.063"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aninu.2023.06.007"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.2527\/1995.73113341x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20164032"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aninu.2021.05.001"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201070399\u20102"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000492853"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.2527\/2006.8461422x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/jas\/skae052"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/137.4.916"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.19103\/AS.2021.0091.01"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anifeedsci.2018.12.004"},{"key":"e_1_2_7_29_1","first-page":"273","volume-title":"Sustainable Swine Nutrition","author":"Kim S. 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