{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T17:49:42Z","timestamp":1782409782410,"version":"3.54.5"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T00:00:00Z","timestamp":1781308800000},"content-version":"vor","delay-in-days":163,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100015103","name":"Japan Racing Association","doi-asserted-by":"publisher","award":["KS"],"award-info":[{"award-number":["KS"]}],"id":[{"id":"10.13039\/100015103","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Science Journal"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study examined the impact of early postpartum uterine oxidative stress and antioxidant activity on subsequent reproductive performance in lactating Holstein\u2013Friesian dairy cows. Uterine flush fluid samples were collected at 2\u20138\u2009weeks postpartum (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200977), and diacron reactive oxygen metabolites (d\u2010ROMs), biological antioxidant capacity (BAP), and oxidation stress index (OSI: d\u2010ROMs\/BAP\u2009\u00d7\u2009100) were calculated. Reproductive performance was classified into one of the following three patterns: Pattern 1, pregnant after first postpartum artificial insemination (AI) (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200923) versus nonpregnant after first postpartum AI (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200954); Pattern 2, pregnant &lt;\u2009120\u2009days postpartum (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200932) versus pregnant \u2265\u2009120\u2009days postpartum (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200945); and Pattern 3, pregnant &lt;\u20093 AIs (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200945) versus pregnant or nonpregnant &gt;\u20093 AIs (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200932). There was a significant difference between the groups in d\u2010ROMs at 5\u2009weeks in Pattern 2 and 7\u2009weeks in Patterns 1 and 3. There was no significant difference between the groups in BAP and OSI at any week. The results indicate that an increase in oxidative stress levels in the early postpartum period affects the reproductive performance of Holstein\u2013Friesian dairy cows.\n                  <\/jats:p>","DOI":"10.1111\/asj.70200","type":"journal-article","created":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T07:07:50Z","timestamp":1781334470000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Oxidative Stress and Antioxidant Activity in Uterine Flush Fluid During Early Postpartum on Reproductive Performance of Lactating Holstein\u2013Friesian Dairy Cows"],"prefix":"10.1111","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8915-7499","authenticated-orcid":false,"given":"Yujiro","family":"Hagita","sequence":"first","affiliation":[{"name":"Fuji Animal Farm Nippon Veterinary and Life Science University  Minamitsuru\u2010gun Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4945-0649","authenticated-orcid":false,"given":"Ryotaro","family":"Miura","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine Rakuno Gakuen University  Ebetsu\u2010shi Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6759-6134","authenticated-orcid":false,"given":"Koumei","family":"Shirasuna","sequence":"additional","affiliation":[{"name":"Department of Animal Science Tokyo University of Agriculture  Atsugi\u2010shi Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Tajima","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine Nippon Veterinary and Life Science University  Musashino\u2010shi Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9815-5715","authenticated-orcid":false,"given":"Kazuhiro","family":"Bandai","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine Nippon Veterinary and Life Science University  Musashino\u2010shi Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadaharu","family":"Ajito","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine Nippon Veterinary and Life Science University  Musashino\u2010shi Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotaka","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine Nippon Veterinary and Life Science University  Musashino\u2010shi Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1751731113000396"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpn.12273"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1163\/156856700X00769"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0093\u2010691X(94)90482\u2010X"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1996.0292"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani12182403"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2007.06.006"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022\u20100302(98)75826\u20106"},{"issue":"2","key":"e_1_2_8_10_1","article-title":"A Simple Test to Monitor Oxidative Stress","volume":"18","author":"Cesarone M. 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