{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:30:37Z","timestamp":1791639037119,"version":"4.3.4"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,2,26]],"date-time":"2013-02-26T00:00:00Z","timestamp":1361836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust Veterinary J"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the efficacy of initial doses of desoxycorticosterone pivalate (<jats:styled-content style=\"fixed-case\">DOCP<\/jats:styled-content>) that are lower and less expensive than the presently recommended initial dose of 2.2\u2009mg\/kg for treating dogs with primary hypoadrenocorticism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective study was performed on 49 dogs with primary hypoadrenocorticism, including 36 with initial<jats:styled-content style=\"fixed-case\">DOCP<\/jats:styled-content>doses less than 2.2\u2009mg\/kg. Medical records were reviewed for clinical data. All study dogs were followed up with telephone calls to owners or veterinarians to determine the date of death or last follow\u2010up. Data were analysed to investigate relationships between initial<jats:styled-content style=\"fixed-case\">DOCP<\/jats:styled-content>dose and survival and serum<jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>a,<jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>and their ratio.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Regardless of their initial<jats:styled-content style=\"fixed-case\">DOCP<\/jats:styled-content>dose, none of the dogs developed uncontrolled hypoadrenocorticism or severe electrolyte abnormalities or clinical problems that would have made an increase in the<jats:styled-content style=\"fixed-case\">DOCP<\/jats:styled-content>dose necessary. Over time, most dogs had a decrease in their<jats:styled-content style=\"fixed-case\">DOCP<\/jats:styled-content>dose in mg\/kg, because of weight gain during treatment. No statistically significant relationships were found between initial<jats:styled-content style=\"fixed-case\">DOCP<\/jats:styled-content>dose and survival or post\u2010treatment serum<jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>a,<jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>or<jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>a\u2009:\u2009<jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>, with the exception of one statistically significant result that suggested lower efficacy for higher doses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Initial<jats:styled-content style=\"fixed-case\">DOCP<\/jats:styled-content>doses less than 2.2\u2009mg\/kg may be effective in controlling serum electrolyte concentrations in dogs with primary hypoadrenocorticism without adversely affecting survival. If confirmed by additional research, these findings would enable practitioners to reduce the cost of<jats:styled-content style=\"fixed-case\">DOCP<\/jats:styled-content>treatment by using lower initial doses, potentially saving the lives of dogs that would otherwise be euthanased because of treatment expense.<\/jats:p><\/jats:sec>","DOI":"10.1111\/avj.12019","type":"journal-article","created":{"date-parts":[[2013,2,26]],"date-time":"2013-02-26T07:09:46Z","timestamp":1361862586000},"page":"77-82","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Lower initial dose desoxycorticosterone pivalate for treatment of canine primary hypoadrenocorticism"],"prefix":"10.1111","volume":"91","author":[{"given":"JA","family":"Bates","sequence":"first","affiliation":[{"name":"Department of Small Animal Clinical Sciences College of Veterinary Medicine Michigan State University East Lansing Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Shott","sequence":"additional","affiliation":[{"name":"Statistical Communications PO Box 671 Harvard Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WD","family":"Schall","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences College of Veterinary Medicine Michigan State University East Lansing Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,2,26]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"394","volume-title":"Canine and feline endocrinology and reproduction","author":"Feldman EC","year":"2004"},{"key":"e_1_2_6_3_1","first-page":"220","article-title":"Hypoadrenocorticism in the dog","volume":"7","author":"Mulnix JA","year":"1971","journal-title":"J Am Anim Hosp Assoc"},{"key":"e_1_2_6_4_1","first-page":"63","article-title":"Canine hypoadrenocorticism: Part I","volume":"51","author":"Klein SC","year":"2010","journal-title":"Can Vet J"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1996.tb02377.x"},{"key":"e_1_2_6_6_1","first-page":"179","article-title":"Canine hypoadrenocorticism: Part II","volume":"51","author":"Klein SC","year":"2010","journal-title":"Can Vet J"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0007-1935(91)90091-Z"},{"key":"e_1_2_6_8_1","doi-asserted-by":"crossref","first-page":"392","DOI":"10.2460\/javma.1993.202.03.392","article-title":"Efficacy of microcrystalline desoxycorticosterone pivalate for treatment of hypoadrenocorticism in dogs. DOCP clinical study group","volume":"202","author":"Lynn RC","year":"1993","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1997.tb00072.x"},{"key":"e_1_2_6_10_1","first-page":"112","article-title":"Mineralocorticoid therapy of spontaneous primary hypoadrenocorticism in 176 dogs","volume":"6","author":"Kintzer PP","year":"1992","journal-title":"J Vet Intern Med"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.239.3.322"}],"container-title":["Australian Veterinary Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Favj.12019","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/avj.12019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T13:36:02Z","timestamp":1715002562000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/avj.12019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,26]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.1111\/avj.12019"],"URL":"https:\/\/doi.org\/10.1111\/avj.12019","archive":["Portico"],"relation":{},"ISSN":["0005-0423","1751-0813"],"issn-type":[{"value":"0005-0423","type":"print"},{"value":"1751-0813","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,26]]},"assertion":[{"value":"2012-07-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-02-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}