{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T02:14:43Z","timestamp":1768443283644,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,3,22]],"date-time":"2013-03-22T00:00:00Z","timestamp":1363910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust Veterinary J"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the sedative, respiratory and cardiovascular effects of subcutaneously administered alfaxalone and butorphanol in a group of hyperthyroid cats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A prospective, single\u2010centre observational study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Client\u2010owned hyperthyroid cats (n = 20) were examined and sedated with alfaxalone (3\u2009mg\/kg) and butorphanol (0.2\u2009mg\/kg) administered subcutaneously. Sedation scores, heart rate, respiratory rate and blood pressure were measured at 15\u2010min intervals during the 45\u2010min observation period and compared with pre\u2010sedation values. At the end of 45\u2009min, cats were assessed to be adequately sedated for oral administration of iodine\u2010131 if there was minimal resistance and an intact gag reflex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The maximum median sedation score was reached 45\u2009min after injection. The lowest mean heart and respiratory rates and blood pressure values occurred 30\u2009min after injection. Significant decreases were noted in respiratory rates at all three time points (P &lt; 0.001). Systolic, diastolic and mean blood pressure measurements were also significantly decreased at 15 and 30\u2009min after injection (P &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Subcutaneously administered alfaxalone and butorphanol can be used for sedation in cats undergoing procedures of short duration. Blood pressure should be monitored because of transient decreases observed in some cats. Further studies are required to determine whether the sedative, respiratory and cardiovascular effects are similar in euthyroid cats.<\/jats:p><\/jats:sec>","DOI":"10.1111\/avj.12034","type":"journal-article","created":{"date-parts":[[2013,3,23]],"date-time":"2013-03-23T06:52:28Z","timestamp":1364021548000},"page":"131-136","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Sedation of hyperthyroid cats with subcutaneous administration of a combination of alfaxalone and butorphanol"],"prefix":"10.1111","volume":"91","author":[{"given":"S","family":"Ramoo","sequence":"first","affiliation":[{"name":"Faculty of Veterinary Science University of Melbourne Werribee Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LA","family":"Bradbury","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Science University of Melbourne Werribee Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GA","family":"Anderson","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Science University of Melbourne Werribee Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LA","family":"Abraham","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Science University of Melbourne Werribee Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,22]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"419","article-title":"Evaluation of acepromazine\/meperidine atropine premedication followed by thiopental anesthesia in the cat","volume":"52","author":"Dyson DH","year":"1988","journal-title":"Can J Vet Res"},{"key":"e_1_2_6_3_1","first-page":"23","article-title":"Evaluation of a xylazine\u2010ketamine hydrochloride combination in the cat","volume":"50","author":"Allen DG","year":"1986","journal-title":"Can J Vet Res"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2995.2010.00555.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.67.8.1362"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2004.225.540"},{"key":"e_1_2_6_7_1","unstructured":"HeitM SchnellM WhittemT PasloskeK.Safety and efficacy of Alfaxane\u2010CD RTU administered once to cats subcutaneously at 10\u2009mg\/kg.In: Proceedings of the 22nd American College of Veterinary Internal Medicine (ACVIM) Forum June 2004 Minneapolis Minnesota USA;432."},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2995.2008.00428.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(01)50008-X"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1999.tb02189.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.2000.tb11858.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.1984.tb00737.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2005.00040.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2008.05.007"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2008.00998.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1972.tb06864.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.162.26.852"},{"key":"e_1_2_6_18_1","first-page":"236","article-title":"Effects of saffan on cardiopulmonary function in healthy cats","volume":"51","author":"Dyson DH","year":"1987","journal-title":"Can J Vet Res"},{"key":"e_1_2_6_19_1","first-page":"262","article-title":"Development of a non\u2010surfactant formulation for alfaxalone through the use of chemically\u2010modified cyclodextrins","volume":"43","author":"Brewster ME","year":"1989","journal-title":"J Parenter Sci Technol"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.2009.00390.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2009.09.004"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.68.7.699"},{"key":"e_1_2_6_23_1","unstructured":"HeitM PasloskeK WhittemT RanasingheMG LiQ.Plasma pharmacokinetics of alfaxalone in cats after administration at 5 and 25\u2009mg\/kg as an intravenous bolus of Alfaxan\u00ae\u2010CD RTU.In: Proceedings of the American College of Veterinary Internal Medicine (ACVIM) Forum June 2004 Minneapolis Minnesota USA;432\u2013433."},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1997.tb04863.x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.2460\/javma.1997.210.09.1279","article-title":"Arterial blood pressure monitoring in anesthetized animals","volume":"210","author":"Wagner AE","year":"1997","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.1998.tb00143.x"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-199807000-00040"}],"updated-by":[{"DOI":"10.1111\/avj.12068","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2013,5,29]],"date-time":"2013-05-29T00:00:00Z","timestamp":1369785600000}}],"container-title":["Australian Veterinary Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Favj.12034","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/avj.12034","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T22:00:25Z","timestamp":1715119225000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/avj.12034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,22]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["10.1111\/avj.12034"],"URL":"https:\/\/doi.org\/10.1111\/avj.12034","archive":["Portico"],"relation":{},"ISSN":["0005-0423","1751-0813"],"issn-type":[{"value":"0005-0423","type":"print"},{"value":"1751-0813","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,22]]},"assertion":[{"value":"2012-09-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-03-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}