{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:10:38Z","timestamp":1773011438679,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,9,23]],"date-time":"2013-09-23T00:00:00Z","timestamp":1379894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust Veterinary J"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:sec><jats:title>Case report<\/jats:title><jats:p>A 13\u2010month\u2010old Thoroughbred filly was diagnosed with osteochondritis dissecans (<jats:styled-content style=\"fixed-case\">OCD<\/jats:styled-content>) of the medial tibial malleolus.<\/jats:p><jats:p>A sponge impregnated with platelet\u2010rich plasma, bone morphogenetic protein\u20102, mesenchymal stem cells and gelatin \u03b2\u2010tricalcium phosphate was applied to the<jats:styled-content style=\"fixed-case\">OCD<\/jats:styled-content>site following arthroscopy and debridement. Postoperative radiography (every week for 16 weeks), computed tomography (<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>) (16 weeks postoperatively), arthroscopy (16 weeks postoperatively) and biopsy of the regenerated tissue (16 weeks postoperatively) were performed to evaluate the outcome.<\/jats:p><jats:p>Radiographically, the defect began to diminish 3 weeks postoperatively and had disappeared by 12 weeks.<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>images showed that the debrided site was filled with ossified tissue and arthroscopy showed that the regenerated tissue was covered with smooth tissue, which a biopsy showed was fibrocartilage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Placing the impregnated sponge in the<jats:styled-content style=\"fixed-case\">OCD<\/jats:styled-content>lesion facilitated satisfactory regeneration of tissue in the debrided area, but the regenerated cartilage was fibrocartilage. This method may be a viable option for the treatment of cases of equine<jats:styled-content style=\"fixed-case\">OCD<\/jats:styled-content>, but further work to determine how to induce hyaline cartilage regeneration is required.<\/jats:p><\/jats:sec>","DOI":"10.1111\/avj.12104","type":"journal-article","created":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T21:28:36Z","timestamp":1444771716000},"page":"411-415","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Bioengineered osteochondral precursor for treatment of osteochondritis dissecans in a Thoroughbred filly"],"prefix":"10.1111","volume":"91","author":[{"given":"N","family":"Tsuzuki","sequence":"first","affiliation":[{"name":"Department of Clinical Veterinary Science Obihiro University of Agriculture and Veterinary Medicine Inada Obihiro Hokkaido 080\u20108555 Japan"},{"name":"The United Graduate School of Veterinary Sciences Gifu University Yanado Gifu 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