{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T22:29:32Z","timestamp":1778279372468,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,11,26]],"date-time":"2014-11-26T00:00:00Z","timestamp":1416960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust Veterinary J"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To survey veterinary practitioners in<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ustralia on how they administer pentosan polysulfate (<jats:styled-content style=\"fixed-case\">PPS<\/jats:styled-content>) to horses and their perceptions of the efficacy of<jats:styled-content style=\"fixed-case\">PPS<\/jats:styled-content>for: the prevention and treatment of osteoarthritis (<jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>), the treatment of<jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>when<jats:styled-content style=\"fixed-case\">PPS<\/jats:styled-content>is combined with other drugs, and the efficacy of<jats:styled-content style=\"fixed-case\">PPS<\/jats:styled-content>compared with other disease\u2010modifying osteoarthritic drugs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Practitioners were contacted by email, which contained a link to an online survey.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 76 responses (34.5%) to the survey were received. Respondents most commonly used<jats:styled-content style=\"fixed-case\">PPS<\/jats:styled-content>as prophylactic therapy prior to competition (80.3%). As a prophylactic agent,<jats:styled-content style=\"fixed-case\">PPS<\/jats:styled-content>was considered by 48.2% of respondents to have high efficacy. The most common dose regimen for prevention and treatment of<jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>was 3\u2009mg\/kg, intramuscularly, once weekly for 4 weeks followed by monthly injections. Most respondents (78%) combined<jats:styled-content style=\"fixed-case\">PPS<\/jats:styled-content>with other drugs for treatment of<jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>. Intra\u2010articular corticosteroids and hyaluronate (<jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content>) was the most common drug combination used with<jats:styled-content style=\"fixed-case\">PPS<\/jats:styled-content>.<jats:styled-content style=\"fixed-case\">PPS<\/jats:styled-content>was preferred as a prophylactic agent when compared with<jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content>(88.7% vs 11.3%). For treating<jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>, 83% of respondents considered a combination of<jats:styled-content style=\"fixed-case\">PPS<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content>and glucosamine to be more efficacious than<jats:styled-content style=\"fixed-case\">PPS<\/jats:styled-content>alone. However, the most common reason not to use this combination was cost (79.1%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>All respondents used<jats:styled-content style=\"fixed-case\">PPS<\/jats:styled-content>for prophylaxis and\/or treatment of<jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>despite limited published scientific evidence proving its efficacy in horses. Further research is necessary to provide evidence of the clinical efficacy of<jats:styled-content style=\"fixed-case\">PPS<\/jats:styled-content>for the prevention and treatment of<jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>in horses.<\/jats:p><\/jats:sec>","DOI":"10.1111\/avj.12266","type":"journal-article","created":{"date-parts":[[2014,11,26]],"date-time":"2014-11-26T06:40:59Z","timestamp":1416984059000},"page":"482-487","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Survey of the therapeutic approach and efficacy of pentosan polysulfate for the prevention and treatment of equine osteoarthritis in veterinary practice in<scp>A<\/scp>ustralia"],"prefix":"10.1111","volume":"92","author":[{"given":"CM","family":"Kramer","sequence":"first","affiliation":[{"name":"Faculty of Veterinary Science The University of Sydney Camperdown New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AS","family":"Tsang","sequence":"additional","affiliation":[{"name":"Research and Clinical Training Unit Faculty of Veterinary Science The University of Sydney Camden New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Koenig","sequence":"additional","affiliation":[{"name":"Research and Clinical Training Unit Faculty of Veterinary Science The University of Sydney Camden New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LB","family":"Jeffcott","sequence":"additional","affiliation":[{"name":"Research and Clinical Training Unit Faculty of Veterinary Science The University of Sydney Camden New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CM","family":"Dart","sequence":"additional","affiliation":[{"name":"Research and Clinical Training Unit Faculty of Veterinary Science The University of Sydney Camden New South Wales Australia"},{"name":"University Veterinary Centre The University of Sydney PMB 4, Narellan Delivery Centre Narellan New South Wales 2567 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AJ","family":"Dart","sequence":"additional","affiliation":[{"name":"University Veterinary Centre The University of Sydney PMB 4, Narellan Delivery Centre Narellan New South Wales 2567 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,11,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-7216-8342-3.50092-9"},{"key":"e_1_2_7_3_1","first-page":"980","article-title":"Pathophysiology of synovitis: clinical signs and examination in horses","volume":"12","author":"Todhunter RJ","year":"1990","journal-title":"Compend Contin Educ Pract Vet"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1982.tb02389.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.116.3.66"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3292.2001.tb00082.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-7216-8342-3.50070-X"},{"key":"e_1_2_7_8_1","first-page":"281","volume-title":"Joint disease in the horse","author":"Little C","year":"1996"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-0172(99)80021-3"},{"key":"e_1_2_7_10_1","unstructured":"LittleC GhoshP BellingerC.Meniscectomy increases aggrecan decoran (PGS2) and biglycan (PG\u2010S1) metabolism in cartilage. 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