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Serum bromide concentrations were determined by colorimetric spectrophotometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>administration the maximum concentration (<jats:styled-content style=\"fixed-case\"><jats:italic>C<\/jats:italic><\/jats:styled-content><jats:sub>max<\/jats:sub>) was 822.11 \u00b1 93.61\u2009mg\/L, volume of distribution (<jats:styled-content style=\"fixed-case\"><jats:italic>V<\/jats:italic><\/jats:styled-content><jats:sub>d<\/jats:sub>) was 0.286 \u00b1 0.031\u2009L\/kg and the clearance (<jats:styled-content style=\"fixed-case\"><jats:italic>C<\/jats:italic><\/jats:styled-content><jats:italic>l<\/jats:italic>) was 0.836 \u00b1 0.255\u2009mL\/h\/kg. After<jats:styled-content style=\"fixed-case\">PO<\/jats:styled-content>administration the<jats:styled-content style=\"fixed-case\"><jats:italic>C<\/jats:italic><\/jats:styled-content><jats:sub>max<\/jats:sub>was 453.86 \u00b1 43.37\u2009mg\/L and the time of maximum concentration (<jats:styled-content style=\"fixed-case\"><jats:italic>T<\/jats:italic><\/jats:styled-content><jats:sub>max<\/jats:sub>) was 108 \u00b1 125\u2009h. The terminal half\u2010life (<jats:italic>t<\/jats:italic><jats:sub>\u00bd<\/jats:sub>) of bromide after<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">PO<\/jats:styled-content>administration was 387.93 \u00b1 115.35\u2009h and 346.72 \u00b1 94.05\u2009h, respectively. The oral bioavailability (<jats:styled-content style=\"fixed-case\"><jats:italic>F<\/jats:italic><\/jats:styled-content>) of bromide was 92%. No adverse reactions were noted in either treatment group during this study. The concentration versus time profiles exhibited secondary peaks, suggestive of gastrointestinal cyclic redistribution of the drug.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and clinical relevance<\/jats:title><jats:p>When administered<jats:styled-content style=\"fixed-case\">PO<\/jats:styled-content>, bromide in sheep has a long half\u2010life (<jats:italic>t<\/jats:italic><jats:sub>\u00bd<\/jats:sub>) of approximately 14 days, with good bioavailability. Potassium bromide is a readily available, affordable salt with a long history of medical use as an anxiolytic, sedative and antiseizure therapy in other species. 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