{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T07:50:17Z","timestamp":1777535417692,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,10,26]],"date-time":"2015-10-26T00:00:00Z","timestamp":1445817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust Veterinary J"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the general clinical presentation and incidence of adverse reactions to Cylap\u00ae RCD vaccinations, of a nature serious enough for veterinary attention, in a Sydney population of pet rabbits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A retrospective survey using hospital databases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nine veterinary hospitals in Sydney participated in a database search for the number of rabbits vaccinated within a 2\u2010year period. The hospitals involved had an identified interest in rabbit medicine and included general, specialist and teaching hospitals. Details of the rabbit, vaccination event and any possible reaction were collected and analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 933 events recorded in 705 rabbits, 17 (1.8%) adverse reactions were observed. Of the adverse events, local injection site reactions (alopecia, abrasions and scabbing) were most common. Other reactions, including systemic signs of gastrointestinal tract stasis, lethargy and forelimb lameness, were also documented. Overall, rabbits presented for vaccination were mostly male (57.7%) and desexed (71.3%), with an average age of 28.1\u2009months (median 19.0, range 1.4\u2013149.8\u2009months) and an average weight at first vaccination of 2.12\u2009kg (median 2.08\u2009kg, range 0.18\u20135.6\u2009kg). A significant association between increasing age and decreased incidence of adverse events was demonstrated (P value, 0.038).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The benefits of vaccination against RCV outweigh the risks of an adverse reaction occurring. Data from this study show that adverse reactions occur infrequently, are generally mild and self\u2010resolving, and decrease in incidence with increasing age. These results are similar to previous field research on wild rabbit colonies and reports from government and industry.<\/jats:p><\/jats:sec>","DOI":"10.1111\/avj.12373","type":"journal-article","created":{"date-parts":[[2015,10,27]],"date-time":"2015-10-27T05:09:13Z","timestamp":1445922553000},"page":"405-411","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Adverse reactions in a population of Sydney pet rabbits vaccinated against rabbit calicivirus"],"prefix":"10.1111","volume":"93","author":[{"given":"T","family":"Tung","sequence":"first","affiliation":[{"name":"Faculty of Veterinary Science The University of Sydney Camden NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Phalen","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Science The University of Sydney Camden NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u2010ALML","family":"Toribio","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Science The University of Sydney Camden NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,10,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1297-9716-43-12"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.1997.tb14354.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jwmg.207"},{"key":"e_1_2_7_5_1","first-page":"459","article-title":"La enfermedad hemorr\u00e1gica viral del conejo: vacunaci\u00f3n y repuesta inmunol\u00f3gica","volume":"10","author":"Arg\u00fcello J","year":"1991","journal-title":"Office Int Epizoot Sci Tech Rev"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2193\/0022-541X(2004)068[0198:SNEOVC]2.0.CO;2"},{"key":"e_1_2_7_7_1","unstructured":"Australian Pesticides and Veterinary Medicines Authority (APVMA).Notice of registration of agricultural and veterinary chemical products:veterinary chemical products. 3 August 1999 edn. APVMA Kingston 1999."},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.233.7.1072"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1647\/1082-6742-24.3.237"},{"key":"e_1_2_7_10_1","unstructured":"StoneT.Rabbit vaccination survey.2011.www.therabbithouse.com\/research\/rabbitvaccinationsurvey.docx. Accessed August 2013."},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.2005.tb12188.x"},{"key":"e_1_2_7_12_1","unstructured":"Australian Pesticides and Veterinary Medicines Authority (APVMA). Adverse Experience Reports Program [1995\u20132010]. APVMA Kingston 2013.www.apvma.gov.au. Accessed September 2015."},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/00480169.2006.36704"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2007.04.012"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781444322958.ch19"},{"key":"e_1_2_7_16_1","volume-title":"Guidelines on pharmacovigilance for medicinal products for veterinary use draft v 3.1. Volume 9B of The rules governing medicinal products in the European Union","author":"Committee for Medicinal Products for Veterinary Use (CVMP)","year":"2009"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781444322958.ch27"},{"key":"e_1_2_7_18_1","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1080\/00031305.1983.10483107","article-title":"Estimation of the intraclass correlation coefficient for the analysis of covariance model","volume":"37","author":"Stanish WM","year":"1983","journal-title":"Am Statist"},{"key":"e_1_2_7_19_1","unstructured":"MitchellS.Manufacturer reports of adverse events in rabbits vaccinated against calicivirus. Zoetis Animal Health October 11 2012."},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.159.4.103"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0962728600000890"},{"key":"e_1_2_7_22_1","volume-title":"Manual of diagnostic tests and vaccines for terrestrial animals 2013","author":"Office International des Epizooties (OIE)","year":"2013"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2006.04.017"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2006.04.002"}],"container-title":["Australian Veterinary Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Favj.12373","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/avj.12373","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T01:34:34Z","timestamp":1718156074000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/avj.12373"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,26]]},"references-count":23,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1111\/avj.12373"],"URL":"https:\/\/doi.org\/10.1111\/avj.12373","archive":["Portico"],"relation":{},"ISSN":["0005-0423","1751-0813"],"issn-type":[{"value":"0005-0423","type":"print"},{"value":"1751-0813","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,26]]},"assertion":[{"value":"2014-02-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-11-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-10-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}