{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T09:52:21Z","timestamp":1786787541532,"version":"build-2736575974"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,5,30]],"date-time":"2016-05-30T00:00:00Z","timestamp":1464566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust Veterinary J"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To identify any prognostic factors that may be associated with the long\u2010term survival of dogs diagnosed with tonsillar squamous cell carcinoma (<jats:styled-content style=\"fixed-case\">TSCC<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The medical records of 15 dogs treated for <jats:styled-content style=\"fixed-case\">TSCC<\/jats:styled-content> were reviewed retrospectively. The signalment, presenting signs, clinical stage, treatments and outcome were documented.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall median survival time (<jats:styled-content style=\"fixed-case\">MST<\/jats:styled-content>) of the dogs in the study was 243 days. There was a 1\u2010and 2\u2010year survival of 40% and 20%, respectively. The results of initial staging had a significant effect on survival, as dogs with only one tonsil affected and no evidence of metastatic disease had a longer <jats:styled-content style=\"fixed-case\">MST<\/jats:styled-content> (637.5\u2009days) than the dogs with local (<jats:styled-content style=\"fixed-case\">MST<\/jats:styled-content>: 134 days) or distant (<jats:styled-content style=\"fixed-case\">MST<\/jats:styled-content>: 75 days) metastatic disease or bilateral tonsillar involvement at the time of initial presentation. Prolonged survival times were reported for dogs undergoing surgery and adjunctive chemotherapy (<jats:styled-content style=\"fixed-case\">MST<\/jats:styled-content>: 464.5\u2009days) for treatment of their <jats:styled-content style=\"fixed-case\">TSCC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical significance<\/jats:title><jats:p>This is the first veterinary study demonstrating an association between prognosis of patients with <jats:styled-content style=\"fixed-case\">TSCC<\/jats:styled-content> and stage at the time of presentation, with long survival times demonstrated for dogs with early\u2010stage disease following an initial treatment protocol that included surgery and chemotherapy. There was no clear association between long survival and additional surgeries for progressive disease; however; further investigation is warranted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/avj.12444","type":"journal-article","created":{"date-parts":[[2016,5,30]],"date-time":"2016-05-30T05:19:17Z","timestamp":1464585557000},"page":"197-202","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Evaluation of the factors contributing to long\u2010term survival in canine tonsillar squamous cell carcinoma"],"prefix":"10.1111","volume":"94","author":[{"given":"J","family":"Grant","sequence":"first","affiliation":[{"name":"Rutland House Referrals, 4 Abbotsfield Road, St Helens Merseyside WA94HU UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"North","sequence":"additional","affiliation":[{"name":"VRCC Veterinary Referrals  Laindon Essex UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2006.00020.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.114.14.341"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1985.tb02184.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1970.tb06125.x"},{"key":"e_1_2_7_6_1","first-page":"567","article-title":"Oral and pharyngeal neoplasia in the dog: a retrospective survey of 361 cases","volume":"175","author":"Todoroff RJ","year":"1979","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1988.tb00318.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2011.01075.x"},{"key":"e_1_2_7_9_1","first-page":"34","volume-title":"TNM classification of tumours in domestic animals","author":"Owen LN","year":"1980"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.57.1.43"},{"key":"e_1_2_7_11_1","first-page":"145","article-title":"Head and neck: squamous cell carcinoma: an overview","volume":"16","author":"Rousseau A","year":"2012","journal-title":"Atlas Genet Cytogenet Oncol Haematol"},{"key":"e_1_2_7_12_1","first-page":"20","article-title":"Overview of platinum chemotherapy in head and neck cancer","volume":"21","author":"Forastiere AA","year":"1994","journal-title":"Semin Oncol"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19941001)74:7<1927::AID-CNCR2820740717>3.0.CO;2-P"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2009-0058erratum"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599811399559"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5829.2011.00275.x"}],"container-title":["Australian Veterinary Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Favj.12444","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/avj.12444","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T16:46:29Z","timestamp":1696351589000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/avj.12444"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,30]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1111\/avj.12444"],"URL":"https:\/\/doi.org\/10.1111\/avj.12444","archive":["Portico"],"relation":{},"ISSN":["0005-0423","1751-0813"],"issn-type":[{"value":"0005-0423","type":"print"},{"value":"1751-0813","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,30]]},"assertion":[{"value":"2015-03-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-09-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-05-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}