{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T18:17:31Z","timestamp":1784830651824,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,5,11]],"date-time":"2016-05-11T00:00:00Z","timestamp":1462924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust Veterinary J"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The virus family <jats:italic>Papillomaviridae<\/jats:italic> has been documented in a wide range of animal species and can cause benign and malignant proliferative lesions. The presence of concurrent lingual papillomas and squamous cell carcinomas (<jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>) in cetaceans has also been documented in both wild and captive populations, suggesting malignant transformation of benign papilloma to <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> may occur in this species.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case report<\/jats:title><jats:p>In 2008, a 38\u2010year\u2010old captive male inshore bottlenose dolphin (<jats:italic>Tursiops aduncus<\/jats:italic>) was diagnosed with papillomatous lesions on the intermandibular frenulum rostral to the tongue and an infiltrative <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> of the soft palate following biopsy and histological analysis. A treatment regimen of piroxicam and doxycycline was initiated with misoprostol as a gastroprotectant. The treatment resulted in a marked reduction in tumour size and reversible hepatotoxicosis. Subsequent biopsies revealed the presence of <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> in the oral cavity; however, the disease remains stable at the time of writing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>To the best of our knowledge, this case is the first report of piroxicam and doxycycline used to treat <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> in a bottlenose dolphin. The treatment was successful in reducing the clinical presentation of the disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/avj.12449","type":"journal-article","created":{"date-parts":[[2016,5,12]],"date-time":"2016-05-12T03:36:55Z","timestamp":1463024215000},"page":"203-207","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Piroxicam and doxycycline treatment for an oral squamous cell carcinoma in an inshore bottlenose dolphin (<i>Tursiops aduncus<\/i>)"],"prefix":"10.1111","volume":"94","author":[{"given":"DT","family":"March","sequence":"first","affiliation":[{"name":"Dolphin Marine Magic Coffs Harbour  New South Wales 2456 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DJ","family":"Blyde","sequence":"additional","affiliation":[{"name":"Seaworld  Gold Coast QLD 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