{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T13:39:09Z","timestamp":1740145149024,"version":"3.37.3"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,8,28]],"date-time":"2016-08-28T00:00:00Z","timestamp":1472342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust Veterinary J"],"published-print":{"date-parts":[[2016,9]]},"abstract":"Objectives<\/jats:title>To describe pulmonary transit time (nPTT<\/jats:styled-content>) and myocardial perfusion (nMP<\/jats:styled-content>) normalised to heart rate in dogs with stable ACVIM<\/jats:styled-content> stage C myxomatous mitral valve disease (MMVD<\/jats:styled-content>) and to assess short\u2010term effects of pimobendan on these variables. We hypothesised that nPTT<\/jats:styled-content> and nMP<\/jats:styled-content> would increase in dogs with MMVD<\/jats:styled-content> compared with normal dogs. Additionally, we hypothesised that treatment with pimobendan would decrease nMP<\/jats:styled-content> and nPTT<\/jats:styled-content> in dogs with MMVD<\/jats:styled-content>.<\/jats:p><\/jats:sec>Design<\/jats:title>Prospective, single\u2010blind study involving 6 normal dogs and 12 dogs with MMVD<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>Dogs with MMVD<\/jats:styled-content> were treated with enalapril and furosemide for at least 1 month prior to examination. All dogs underwent standard and contrast echocardiographic examinations at the beginning of the study (T0<\/jats:styled-content>). At this time, MMVD<\/jats:styled-content> dogs were randomly assigned to receive either pimobendan (0.4\u20130.6\u2009mg\/kg) or not. All dogs with MMVD<\/jats:styled-content> were re\u2010evaluated by standard and contrast echocardiography after 1 week (T1<\/jats:styled-content>) and nPTT<\/jats:styled-content> and nMP<\/jats:styled-content> were measured.<\/jats:p><\/jats:sec>Results<\/jats:title>\nnPTT<\/jats:styled-content> was significantly increased in dogs with MMVD<\/jats:styled-content> (P\u2009=\u20090.0063), compared with normal dogs. It was significantly decreased at T1<\/jats:styled-content> in dogs receiving pimobendan (P\u2009=\u20090.0250). The nMP<\/jats:styled-content> was not significantly different in dogs with MMVD<\/jats:styled-content>, compared with healthy dogs (P\u2009=\u20090.2552), and it was not significantly different at T1<\/jats:styled-content> in the treatment group (P\u2009=\u20090.8798).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Contrast echocardiography was a valid, complementary tool for echocardiographic analysis of dogs with MMVD<\/jats:styled-content>. Pimobendan decreased nPTT<\/jats:styled-content> in dogs affected by MMVD<\/jats:styled-content>. Myocardial perfusion was not different in dogs with severe MMVD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/avj.12480","type":"journal-article","created":{"date-parts":[[2016,8,29]],"date-time":"2016-08-29T04:55:19Z","timestamp":1472446519000},"page":"324-328","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of pimobendan on myocardial perfusion and pulmonary transit time in dogs with myxomatous mitral valve disease: a pilot study"],"prefix":"10.1111","volume":"94","author":[{"given":"SM","family":"Apple","sequence":"first","affiliation":[{"name":"Department of Small Animal Clinical Sciences Virginia\u2013Maryland College of Veterinary Medicine Blacksburg VA 24060 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